Cerebellar gray matter and lobular volumes correlate with core autism symptoms.
Cerebellar gray matter and lobular volumes correlate with core autism symptoms.
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DOI：
10.1016/j.nicl.2015.02.007
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发表时间：
2015
影响因子：
4.2
通讯作者：
Stoodley, Catherine J.
中科院分区：
文献类型：
--
作者：
DMello, Anila M.;Crocetti, Deana;Mostofsky, Stewart H.;Stoodley, Catherine J.
小脑的神经解剖差异是自闭症谱系障碍（ASD）中最一致的发现之一，但对于小脑功能障碍与ASD核心症状之间的关系知之甚少。新出现的小脑感觉运动和认知亚区为解释ASD中小脑发现的功能意义提供了一个新框架。在此，我们使用两种互补的分析方法——基于全脑体素的形态测量学（VBM）和SUIT小脑图谱——对35名ASD儿童和35名正常发育（TD）儿童（平均年龄10.4 ± 1.6岁；范围8 - 13岁）的小脑区域灰质（GM）和小叶体积测量进行研究。为了检验小脑结构与ASD核心症状之间的关系，我们计算了自闭症诊断观察量表（ADOS）和自闭症诊断访谈（ADI）的得分与VBM及体积数据之间的相关性。VBM和SUIT分析均显示ASD儿童小脑VII小叶（ Crus I/II）的灰质减少。不同小脑亚区的区域和小叶灰质减少程度与社交互动、沟通和重复行为症状的严重程度相关。结构差异和行为相关性集中在右侧小脑Crus I/II，该区域与额顶叶和默认模式网络显示出结构和功能连接。这些结果强调了小脑内部位置对ASD结构差异潜在功能影响的重要性，并表明小脑右侧Crus I/II的灰质差异与ASD核心特征相关。
小脑是自闭症中最一致的异常部位之一。
我们使用两种独立的方法研究了自闭症中的小脑结构。
自闭症儿童的小脑几个区域的灰质减少。
小脑灰质减少的程度可预测自闭症核心症状的严重程度。
结构差异和行为相关性集中在小脑Crus I/II。
Neuroanatomical differences in the cerebellum are among the most consistent findings in autism spectrum disorder (ASD), but little is known about the relationship between cerebellar dysfunction and core ASD symptoms. The newly-emerging existence of cerebellar sensorimotor and cognitive subregions provides a new framework for interpreting the functional significance of cerebellar findings in ASD. Here we use two complementary analyses — whole-brain voxel-based morphometry (VBM) and the SUIT cerebellar atlas — to investigate cerebellar regional gray matter (GM) and volumetric lobular measurements in 35 children with ASD and 35 typically-developing (TD) children (mean age 10.4 ± 1.6 years; range 8–13 years). To examine the relationships between cerebellar structure and core ASD symptoms, correlations were calculated between scores on the Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview (ADI) and the VBM and volumetric data. Both VBM and the SUIT analyses revealed reduced GM in ASD children in cerebellar lobule VII (Crus I/II). The degree of regional and lobular gray matter reductions in different cerebellar subregions correlated with the severity of symptoms in social interaction, communication, and repetitive behaviors. Structural differences and behavioral correlations converged on right cerebellar Crus I/II, a region which shows structural and functional connectivity with fronto-parietal and default mode networks. These results emphasize the importance of the location within the cerebellum to the potential functional impact of structural differences in ASD, and suggest that GM differences in cerebellar right Crus I/II are associated with the core ASD profile. The cerebellum is one of the most consistent sites of abnormality in autism. We investigated cerebellar structure in autism using two independent methods. Cerebellar gray matter was reduced in several regions in children with autism. The degree of cerebellar gray matter reduction predicted core autism symptom severity. Structural differences and behavioral correlations converged on cerebellar Crus I/II.
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影响因子：
4.7
作者：
Duerden, Emma G.;Mak-Fan, Kathleen M.;Roberts, S. Wendy
通讯作者：
Roberts, S. Wendy
影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
DOI：
10.1097/00004583-200403000-00018
发表时间：
2004-03-01
影响因子：
13.3
作者：
Akshoomoff, N;Lord, C;Courchesne, E
通讯作者：
Courchesne, E
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
158.5
作者：
COURCHESNE, E;YEUNGCOURCHESNE, R;JERNIGAN, TL
通讯作者：
JERNIGAN, TL