The True Host/s of Picobirnaviruses.
The True Host/s of Picobirnaviruses.
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小核糖核酸病毒的真正宿主。
DOI：
10.3389/fvets.2020.615293
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发表时间：
2020
影响因子：
3.2
通讯作者：
Malik YS
中科院分区：
文献类型：
--
作者：
Ghosh S;Malik YS
微RNA病毒（Picobirnaviruses，PBV）是一种双节段双链RNA病毒，已在包括无脊椎动物在内的多种动物物种和环境样品中检测到。由于PBV普遍存在于人类和其他有或无腹泻的动物的粪便/肠道内容物中，因此它们被认为是哺乳动物和禽类物种的机会性肠道病原体。然而，该病毒仍有待于在动物细胞培养物或无菌动物中繁殖。最近，经典定义的原核基序，核糖体结合位点序列，已被确定上游推定的开放阅读框/s在PBV和PBV样序列从人类，各种动物，和环境样品，这表明PBV可能是原核病毒。另一方面，基于检测到一些新的PBV样RNA依赖的RNA聚合酶序列，使用替代线粒体遗传密码（霉菌或无脊椎动物的）进行翻译，并对这些序列进行密码子使用偏好的主成分分析，已经提出PBV可能是具有线粒体病毒生活方式的真菌病毒。这些相互矛盾的观察结果需要进一步研究，以确定PBV的真正宿主，这仍然存在争议。在这篇小综述中，我们重点关注了引起关于PBV真正宿主的辩论的各种发现。
Picobirnaviruses (PBVs) are bisegmented double-stranded RNA viruses that have been detected in a wide variety of animal species including invertebrates and in environmental samples. Since PBVs are ubiquitous in feces/gut contents of humans and other animals with or without diarrhea, they were considered as opportunistic enteric pathogens of mammals and avian species. However, the virus remains to be propagated in animal cell cultures, or in gnotobiotic animals. Recently, the classically defined prokaryotic motif, the ribosomal binding site sequence, has been identified upstream of putative open reading frame/s in PBV and PBV-like sequences from humans, various animals, and environmental samples, suggesting that PBVs might be prokaryotic viruses. On the other hand, based on the detection of some novel PBV-like RNA-dependent RNA polymerase sequences that use the alternative mitochondrial genetic code (that of mold or invertebrates) for translation, and principal component analysis of codon usage bias for these sequences, it has been proposed that PBVs might be fungal viruses with a lifestyle reminiscent of mitoviruses. These contradicting observations warrant further studies to ascertain the true host/s of PBVs, which still remains controversial. In this minireview, we have focused on the various findings that have raised a debate on the true host/s of PBVs.
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影响因子：
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