Biosensors as a future diagnostic approach for COVID-19.

Biosensors as a future diagnostic approach for COVID-19.
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DOI:
10.1016/j.lfs.2021.119117
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发表时间:
2021-05-15
期刊:
影响因子:
6.1
通讯作者:
Hetta HF
Hetta HF
中科院分区:
医学2区
文献类型:
--
作者:
Abid SA;Ahmed Muneer A;Al-Kadmy IMS;Sattar AA;Beshbishy AM;Batiha GE;Hetta HF

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生物传感器是临床诊断、食品加工和环境监测中用于检测各种分析物,特别是病毒的重要装置。这些生物传感器为实时定性和定量检测传染病提供了快速有效的工具。在这里,我们报告了基于各种技术的生物传感器的发展。此外,我们将解释目前用于病毒检测的最常见的生物传感器的机制、优点和缺点,这些生物传感器可以是光学的(例如,表面增强拉曼散射(Sers)、表面等离子体共振(SPR))和电化学生物传感器。基于此,本文介绍了利用血红蛋白β链和特异性抗体分别与SARS-CoV-2抗原结合的两种生物传感器检测SARS-CoV-2(COVID-19的病原体)的方法。
Biosensors are important devices in clinical diagnostics, food processing, and environmental monitoring for detecting various analytes, especially viruses. These biosensors provide rapid and effective instruments for qualitative and quantitative detection of infectious diseases in real-time. Here, we report the development of biosensors based on various techniques. Additionally, we will explain the mechanisms, advantages, and disadvantages of the most common biosensors that are currently used for viral detection, which could be optical (e.g., surface-enhanced Raman scattering (SERS), Surface plasmon resonance (SPR)) and electrochemical biosensors. Based on that, this review recommends methods for efficient, simple, low-cost, and rapid detection of SARS-CoV-2 (the causative agent of COVID-19) that employ the two types of biosensors depending on attaching hemoglobin β-chain and binding of specific antibodies with SARS-CoV-2 antigens, respectively.
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