Strain and stress variations in the human amniotic membrane and fresh corpse autologous sciatic nerve anastomosis in a model of sciatic nerve injury.
Strain and stress variations in the human amniotic membrane and fresh corpse autologous sciatic nerve anastomosis in a model of sciatic nerve injury.
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DOI：
10.3969/j.issn.1673-5374.2012.23.003
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发表时间：
2012-08-15
影响因子：
6.1
通讯作者：
Zhu Q
中科院分区：
文献类型：
--
作者：
Peng C;Zhang Q;Yang Q;Zhu Q
在新鲜的中国人正常尸体上建立了10 mm长的坐骨神经损伤模型。从健康母体胎盘中收获羊膜，并制备成多层、卷曲、管状标本。分别用自体坐骨神经和人羊膜制作坐骨神经损伤模型。拉伸实验结果显示，人羊膜移植坐骨神经损伤模型的最大载荷、最大位移、最大应力和最大应变均大于自体神经吻合组。人羊膜和坐骨神经的应变-应力曲线在第一阶段呈指数变化，第二和第三阶段为弹性变形曲线，第四阶段为塑性变形曲线，此时试件失去承载能力。实验结果表明，人羊膜和自体坐骨神经具有相似的应力-应变曲线，良好的弹性性能，在吻合损伤坐骨神经时具有一定的应变和应力能力。
A 10-mm long sciatic nerve injury model was established in fresh normal Chinese patient cadavers. Amniotic membrane was harvested from healthy maternal placentas and was prepared into multilayered, coiled, tubular specimens. Sciatic nerve injury models were respectively anastomosed using the autologous cadaveric sciatic nerve and human amniotic membrane. Tensile test results showed that maximal loading, maximal displacement, maximal stress, and maximal strain of sciatic nerve injury models anastomosed with human amniotic membrane were greater than those in the autologous nerve anastomosis group. The strain-stress curves of the human amniotic membrane and sciatic nerves indicated exponential change at the first phase, which became elastic deformation curves at the second and third phases, and displayed plastic deformation curves at the fourth phase, at which point the specimens lost their bearing capacity. Experimental findings suggested that human amniotic membranes and autologous sciatic nerves exhibit similar stress-strain curves, good elastic properties, and certain strain and stress capabilities in anastomosis of the injured sciatic nerve.
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