Plasma NEFA storage in adipose tissue in the postprandial state: sex-related and regional differences.
Plasma NEFA storage in adipose tissue in the postprandial state: sex-related and regional differences.
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血浆NEFA在餐后状态下的脂肪组织中存储：与性别有关的区域差异。
DOI：
10.1007/s00125-008-1126-5
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发表时间：
2008-11
期刊：
影响因子：
8.2
通讯作者：
Jensen, M. D.
中科院分区：
文献类型：
--
作者：
Koutsari, C.;Snozek, C. L. H.;Jensen, M. D.
我们最近报道，在活体人体内，循环中的一小部分非酯化脂肪酸(NEFA)是通过直接吸收后的皮下脂肪储存的，这一途径可能有利于女性下体脂肪的分布。在目前的研究中，我们研究了性别和地区差异在餐后条件下皮下脂肪组织中血浆NEFA的储存情况。午餐后一小时，体重正常的男性和女性接受~45微米Ci[1-14C]油酸盐静脉注射，然后定时进行皮下脂肪活检。之前的早餐要么是正常的，要么是高脂肪的；高脂肪的早餐被用来在吸收后范围内创造餐后油酸浓度。脂肪组织中NEFA示踪剂的储存(DPM/g脂肪)在女性中更大；在两性中，腹部脂肪比股骨脂肪更渴望储存示踪剂。女性全身皮下脂肪中储存的示踪剂比例高于男性(分别为27±3%和8±1%，P<；0.0001)。在食用高脂肪早餐和普通脂肪早餐的人之间，没有观察到示踪剂存储方面的显著差异。餐后通过直接摄取在皮下脂肪中储存的NEFA约占女性NEFA处置的25%，但男性在广泛的循环NEFA浓度范围内占10%。它在上半身皮下脂肪中的含量大于下半身皮下脂肪，有利于上半身脂肪的积累，无论男女。
We recently reported that a small fraction of circulating non-esterified fatty acids (NEFA) is stored through direct uptake in subcutaneous fat in postabsorptive humans in vivo and that this pathway may favor a lower-body fat distribution in women. In the present study, we examined sex and regional differences in storage of plasma NEFA in subcutaneous adipose tissue during postprandial conditions. One hour after lunch, normal-weight men and women received an intravenous bolus of ~45 µCi [1-14C]oleate followed by timed subcutaneous fat biopsies. The preceding breakfast was either a normal- or high-fat meal; the high-fat breakfast was used to create postprandial oleate concentrations in the postabsorptive range. Storage of the NEFA tracer in adipose tissue (dpm/g lipid) was greater in women; in both sexes abdominal fat stored tracer more avidly than femoral fat. A greater fraction of the administered tracer was stored in whole-body subcutaneous fat of women than men (27±3% vs. 8±1%, respectively, P <0.0001). No significant differences in tracer storage were observed between those consuming the high- vs. normal-fat breakfast. Postprandial NEFA storage in subcutaneous fat through direct uptake accounts for ~25% of NEFA disposal in women, but <10% in men in a wide range of circulating NEFA concentrations. It is greater in the upper- than lower-body subcutaneous fat, favoring upper-body fat accumulation in both sexes.
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影响因子：
--
作者：
DIGIROLAMO, M;MENDLINGER, S;FERTIG, JW
通讯作者：
FERTIG, JW
影响因子：
7.7
作者：
Bickerton, Alex S. T.;Roberts, Rachel;Frayn, Keith N.
通讯作者：
Frayn, Keith N.
影响因子：
--
作者：
MILES, JM;ELLMAN, MG;JENSEN, MD
通讯作者：
JENSEN, MD
DOI：
10.1152/ajpendo.00340.2004
发表时间：
2005-03-01
影响因子：
5.1
作者：
Uranga, AP;Levine, J;Jensen, M
通讯作者：
Jensen, M
影响因子：
--
作者：
EDENS, NK;FRIED, SK;LEIBEL, RL
通讯作者：
LEIBEL, RL