Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis.
Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis.
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DOI：
10.1111/1759-7714.12181
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发表时间：
2015-05
期刊：
影响因子：
2.9
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Ma Y;Fan M;Dai L;Kang X;Liu Y;Sun Y;Xiong H;Liang Z;Yan W;Chen K
非小细胞肺癌（NSCLC）占肺癌的80%，其中肺鳞状细胞癌（SQCC）是主要类型之一。与肺腺癌相比，肺SQCC的治疗进展不足。早期SQCC的主要治疗方法是手术。然而，影响早期肺SQCC手术治疗疗效的因素仍不清楚。在这项研究中，我们研究了常用的肺SQCC诊断标志物p63，p40和细胞角蛋白（CK）5/6在预后中的意义。76例早期肺SQCC（N0）来自我们的肺癌数据库（2000年1月至2009年12月）。采用组织芯片和免疫组织化学方法检测p63、p40和CK5/6的表达。检查每种标志物的表达水平对患者存活率的影响。p63、p40和CK5/6检测肺SQCC的敏感性和特异性分别为87.0%和81.0%、75.9%和97.9%、78.9%和97.7%。p63、CK5/6高表达或两者同时高表达者生存率高于低表达者（P <0.05）。p40表达水平对生存期无影响（P> 0.05）。多因素分析显示p63高表达、p63 + CK5/6共表达是影响预后的独立因素。术后早期肺SQCC患者应常规行p63和CK5/6免疫组化染色检测。其意义不仅在于鉴别诊断，而且在确定预后。
Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancers, and lung squamous cell carcinoma (SQCC) is one of the main types. Advances in the treatment of lung SQCC are lacking when compared to lung adenocarcinoma. The main treatment for early-stage SQCC is surgery. However, factors affecting the efficacy of surgical treatments for early-stage lung SQCC remain unclear. In this study, we examined the significance of commonly used lung SQCC diagnostic markers p63, p40, and cytokeratin (CK)5/6 in prognosis. Seventy-six cases of early-stage lung SQCC (N0) were obtained from our lung cancer database (January 2000 to December 2009). Tissue microarray and immunohistochemical (IHC) staining were used to detect the expression of p63, p40, and CK5/6. The effect of the expression level of each marker on patients' survival was examined. Sensitivity and specificity of each marker for detecting lung SQCC was 87.0% and 81.0% for p63, 75.9% and 97.9% for p40, and 78.9% and 97.7% for CK5/6. Survival rates of patients with high expression levels of p63 or CK5/6 or both were higher than in patients with low expression levels (P < 0.05). Expression levels of p40 had no effect on survival (P > 0.05). Multivariate analysis showed that high levels of p63 expression p63+CK5/6 co-expression were independent prognostic factors for good survival. IHC staining detection of p63 and CK5/6 in specimens should be routinely performed in postoperative early-stage lung SQCC patients. Its significance lies not only in differential diagnosis, but also in determining prognosis.
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影响因子：
2.8
作者：
Downey, Paul;Cummins, Robert;Gulmann, Christian
通讯作者：
Gulmann, Christian
影响因子：
1.2
作者：
Pelosi, Giuseppe;Sonzogni, Angelica;Viale, Giuseppe
通讯作者：
Viale, Giuseppe
影响因子：
4.6
作者：
Whithaus, Kenneth;Fukuoka, Junya;Jagirdar, Jaishree
通讯作者：
Jagirdar, Jaishree
影响因子：
5.6
作者：
Nonaka, Daisuke
通讯作者：
Nonaka, Daisuke
DOI：
10.1158/1078-0432.ccr-09-3352
发表时间：
2010-07-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Solis LM;Behrens C;Dong W;Suraokar M;Ozburn NC;Moran CA;Corvalan AH;Biswal S;Swisher SG;Bekele BN;Minna JD;Stewart DJ;Wistuba II
通讯作者：
Wistuba II