Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment.
Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment.
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DOI：
10.1021/nn304332s
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发表时间：
2013-03-26
期刊：
影响因子：
17.1
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Wang, Yucai;Black, Kvar C. L.;Luehmann, Hannah;Li, Weiyang;Zhang, Yu;Cai, Xin;Wan, Dehui;Liu, Si-Yun;Li, Max;Kim, Paul;Li, Zhi-Yuan;Wang, Lihong V.;Liu, Yongjian;Xia, Younan
金纳米六足体是一类新型的光学可调纳米结构，由一个八面体核心和在其顶点生长的六个臂组成。通过控制臂的长度，其局域表面等离子体共振峰可从可见光区调谐到近红外区，以便光深入穿透软组织。在此，我们通过与金纳米棒和纳米笼进行对比，比较了金纳米六足体作为光热换能器在治疗诊断应用中的体外和体内性能。虽然所有这些金纳米结构都能吸收近红外光并将其转化为热，但对于制备态和聚乙二醇化的纳米结构，金纳米六足体在体外都表现出最高的细胞摄取率和最低的细胞毒性。体内药代动力学研究表明，在小鼠乳腺癌模型中，聚乙二醇化的金纳米六足体具有显著的血液循环和肿瘤累积。光热治疗后，如通过氟 - 18 - 脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F - FDG PET/CT）所测定的，所有这些金纳米结构在原位都产生了大量热量，并且肿瘤代谢大幅降低。综合来看，我们可以得出结论：就光热破坏和增强造影诊断而言，金纳米六足体是癌症治疗诊断的有前途的候选者。
Gold nanohexapods represent a novel class of optically tunable nanostructures consisting of an octahedral core and six arms grown on its vertices. By controlling the length of the arms, their localized surface plasmon resonance peaks could be tuned from the visible to the near-infrared region for deep penetration of light into soft tissues. Herein we compare the in vitro and in vivo capabilities of Au nanohexapods as photothermal transducers for theranostic applications by benchmarking against those of Au nanorods and nanocages. While all these Au nanostructures could absorb and convert near-infrared light into heat, Au nanohexapods exhibited the highest cellular uptake and the lowest cytotoxicity in vitro for both the as-prepared and PEGylated nanostructures. In vivo pharmacokinetic studies showed that the PEGylated Au nanohexapods had significant blood circulation and tumor accumulation in a mouse breast cancer model. Following photothermal treatment, substantial heat was produced in situ and the tumor metabolism was greatly reduced for all these Au nanostructures, as determined with 18F-flourodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Combined together, we can conclude that Au nanohexapods are promising candidates for cancer theranostics in terms of both photothermal destruction and contrast-enhanced diagnosis.
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影响因子：
38.3
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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