Herpes simplex virus type 2 trends in relation to the HIV epidemic in northern Malawi.

Herpes simplex virus type 2 trends in relation to the HIV epidemic in northern Malawi.
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DOI:
10.1136/sti.2008.030056
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发表时间:
2008-10
影响因子:
3.6
通讯作者:
Fine PE
Fine PE
中科院分区:
医学2区
文献类型:
--
作者:
Glynn JR;Crampin AC;Ngwira BM;Ndhlovu R;Mwanyongo O;Fine PE

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在非洲大部分地区发现的单纯疱疹病毒2型(HSV - 2)的高流行率是早于艾滋病流行,还是在某种程度上是艾滋病流行的结果,目前尚不清楚。在一个非洲农村社区,在艾滋病病毒(HIV)流行率急剧上升的时期,对HSV - 2流行趋势进行了评估,并探讨了将产前门诊(ANC)监测作为一种估计社区HSV - 2流行率的方法。 1988 - 1990年、1998 - 2001年和2002 - 2005年,在马拉维卡龙加区进行分枝杆菌疾病病例对照研究时,对社区对照组的HSV - 2血清阳性率进行了测定,同时在1999 - 2000年对作为HIV监测一部分的产前门诊就诊妇女进行了测定。在此期间,HIV流行率从4%上升到12%。 在所有时期,HSV - 2流行率都随年龄急剧上升,且女性高于男性。在排除移民后,没有证据表明不同时期HSV - 2流行率有变化。产前门诊组的女性HSV - 2流行率低于社区女性,但产前门诊流行率与同年龄组男女综合流行率相近。 这项研究表明,HSV - 2在艾滋病流行之前就已经广泛存在,并且没有受到艾滋病的很大影响。它还证明了产前门诊监测对于估计社区HSV - 2流行率可能是有用的。
It is unclear whether the high prevalence of herpes simplex virus type 2 (HSV-2) found in much of Africa predates the HIV epidemic or is, to some extent, a consequence of it. HSV-2 prevalence trends in a rural African community were assessed over a period in which HIV prevalence rose sharply, and antenatal clinic (ANC) surveillance was explored as a method of estimating community HSV-2 prevalence. HSV-2 seroprevalence was determined among community controls seen for case–control studies of mycobacterial disease in Karonga district, Malawi, in 1988–90, 1998–2001 and 2002–5, and in women attending ANC as part of surveillance for HIV in 1999–2000. Over this period HIV prevalence rose from 4% to 12%. HSV-2 prevalence in all periods increased sharply with age and was higher in women than in men. After excluding migrants, there was no evidence of change in HSV-2 prevalence in the different periods. Women in the ANC group had lower HSV-2 prevalence than those in the community, but the ANC prevalence was a good approximation to the combined male and female prevalence for the same age group. This study suggests that HSV-2 was already widespread before the HIV epidemic and has not been greatly influenced by it. It also demonstrates that ANC surveillance may be useful for estimating community HSV-2 prevalence.
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