Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk.
Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk.
复制标题
DOI：
10.1371/journal.pone.0030951
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wong RH
中科院分区：
文献类型：
--
作者：
Lin IH;Ho ML;Chen HY;Lee HS;Huang CC;Chu YH;Lin SY;Deng YR;He YH;Lien YH;Hsu CW;Wong RH
胰岛素样生长因子（IGFs）是生长激素的介质;它们对细胞增殖和分化有影响。此外，IGFBP-3可抑制IGFs的促有丝分裂作用。有趣的是，茶多酚可以显著降低IGF 1和增加IGFBP 3。在这项研究中，我们评估了吸烟，绿色茶消费，以及IGF 1，IGF 2和IGFBP 3多态性对肺癌风险的影响。研究对象包括170例原发性肺癌患者和340例健康对照者，研究对象的吸烟习惯和饮用绿色茶的情况。通过聚合酶链反应鉴定IGF 1、IGF 2和IGFBP 3的基因型。肺癌病例中吸烟、每天饮用少于一杯绿色茶、接触烹饪烟雾和肺癌家族史的比例高于对照组。在调整混杂效应后，与每天喝一杯以上绿色茶的吸烟者相比，从未喝过绿色茶的吸烟者的风险升高（比值比（OR）= 13.16，95%置信区间（CI）= 2.96-58.51）。 吸烟和绿色茶消费之间的相互作用对肺癌的风险也被观察到。在每天饮用1杯以上的绿色茶饮用者中，IGF 1（CA）19/（CA）19和（CA）19/X基因型携带者与IGF 1 X/X基因型携带者相比，患肺癌的风险显著降低（OR= 0.06，95%CI =0.01-0.44）。 吸烟诱发肺癌的发生可能受到饮用绿色茶及其生长因子环境的调节。
Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3 polymorphisms, on lung cancer risk. Questionnaires were administered to obtain the subjects' characteristics, including smoking habits and green tea consumption from 170 primary lung cancer cases and 340 healthy controls. Genotypes for IGF1, IGF2, and IGFBP3 were identified by polymerase chain reaction. Lung cancer cases had a higher proportion of smoking, green tea consumption of less than one cup per day, exposure to cooking fumes, and family history of lung cancer than controls. After adjusting the confounding effect, an elevated risk was observed in smokers who never drank green tea, as compared to smokers who drank green tea more than one cup per day (odds ratio (OR) = 13.16, 95% confidence interval (CI) = 2.96–58.51). Interaction between smoking and green tea consumption on lung cancer risk was also observed. Among green tea drinkers who drank more than one cup per day, IGF1 (CA)19/(CA)19 and (CA)19/X genotypes carriers had a significantly reduced risk of lung cancer (OR = 0.06, 95% CI = 0.01–0.44) compared with IGF1 X/X carriers. Smoking-induced pulmonary carcinogenesis could be modulated by green tea consumption and their growth factor environment.
登录
查看更多内容
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
5
作者：
Chang, Chin-Hao;Hsiao, Chin-Fu;Hsiung, Chao A.
通讯作者：
Hsiung, Chao A.
影响因子：
3.2
作者：
Ogawa, K;Tsubono, Y;Hisamichi, S
通讯作者：
Hisamichi, S
DOI：
10.1016/j.bbrc.2006.05.080
发表时间：
2006-07-21
影响因子：
3.1
作者：
Kim, Yoon Jun;Yoon, Jung-Hwan;Lee, Hyo-Suk
通讯作者：
Lee, Hyo-Suk
影响因子：
4.9
作者：
ODell, SD;Miller, GJ;Day, INM
通讯作者：
Day, INM