Activation and Sorting of Human White Blood Cells
Activation and Sorting of Human White Blood Cells
复制标题
人类白细胞的激活和分选
DOI：
10.1023/a:1009930322047
复制
发表时间：
1998
影响因子：
2.8
通讯作者：
R. Austin
中科院分区：
文献类型：
--
作者：
R. Carlson;C. Gabel;Shirley S. Chan;R. Austin
We demonstrate a novel activation behavior of human leucocyte adhesion under physiological flow conditions in a microfabricated silicon array of channels with length scales similar to those of human capillaries. Vital nuclei stains and cell specific, flourochrome labeled antibodies reveal that the equilibrium distribution of stuck cells in the arrays displays a strong dependence on cell type and nuclear morphology, and there is eventual separation of the two cell types in the array. The distortion of the cells is the same as they experience in vivo and the response of the granulocytes is consistent with a model describing adhesion as a function of the distortion of the cell by its environment; in other words, activated adhesion. We propose that this complex non-random behavior is due to a deformation activated change in the cells relevant to observed in vivo behavior.
影响因子：
3.4
作者：
BRODY, JP;HAN, YQ;BITENSKY, M
通讯作者：
BITENSKY, M
影响因子：
56.9
作者：
JACKMAN, RJ;WILBUR, JL;WHITESIDES, GM
通讯作者：
WHITESIDES, GM
影响因子：
3.4
作者：
EVANS, E;YEUNG, A
通讯作者：
YEUNG, A