Theta, mental flexibility, and post-traumatic stress disorder: connecting in the parietal cortex.
Theta, mental flexibility, and post-traumatic stress disorder: connecting in the parietal cortex.
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DOI：
10.1371/journal.pone.0123541
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Pang EW
中科院分区：
文献类型：
--
作者：
Dunkley BT;Sedge PA;Doesburg SM;Grodecki RJ;Jetly R;Shek PN;Taylor MJ;Pang EW
创伤后应激障碍（PTSD）是一种以重新体验、逃避、麻木和过度兴奋为特征的心理健康损伤。虽然这种疾病的病因已经被很好地理解了，但关于PTSD中认知后遗症的普遍存在争议。特别是，关于执行功能和心理灵活性的缺陷，有相互矛盾的报道。人们对这种缺陷背后的神经变化所知甚少。在这里，我们使用脑磁图研究了战斗相关创伤后应激障碍（所有男性，平均年龄= 37.4,n = 18）与军事对照组（所有男性，平均年龄= 33.05,n = 19）组在心理灵活性任务中的功能连通性差异。我们观察到，与对照组相比，PTSD组的θ波连通性大幅增加。PTSD组在注意力要求更高的任务中表现不佳，其特征是“晚期”θ波超连通性，集中在涉及右顶叶皮层的网络连接中。此外，我们观察到该区域的连通性强度与许多认知行为结果（包括注意力、抑郁和焦虑的测量）之间存在显著相关性。这些发现表明，大规模网络中神经同步的非典型协调导致PTSD人群在时间、注意力要求高的任务中精神灵活性的缺陷，这种网络超连通性的倾向可能在这种疾病中明显的认知后遗症中起着更普遍的作用。
Post-traumatic stress disorder (PTSD) is a mental health injury characterised by re-experiencing, avoidance, numbing and hyperarousal. Whilst the aetiology of the disorder is relatively well understood, there is debate about the prevalence of cognitive sequelae that manifest in PTSD. In particular, there are conflicting reports about deficits in executive function and mental flexibility. Even less is known about the neural changes that underlie such deficits. Here, we used magnetoencephalography to study differences in functional connectivity during a mental flexibility task in combat-related PTSD (all males, mean age = 37.4, n = 18) versus a military control (all males, mean age = 33.05, n = 19) group. We observed large-scale increases in theta connectivity in the PTSD group compared to controls. The PTSD group performance was compromised in the more attentionally-demanding task and this was characterised by 'late-stage' theta hyperconnectivity, concentrated in network connections involving right parietal cortex. Furthermore, we observed significant correlations with the connectivity strength in this region with a number of cognitive-behavioural outcomes, including measures of attention, depression and anxiety. These findings suggest atypical coordination of neural synchronisation in large scale networks contributes to deficits in mental flexibility for PTSD populations in timed, attentionally-demanding tasks, and this propensity toward network hyperconnectivity may play a more general role in the cognitive sequelae evident in this disorder.
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