Immunotherapy of pancreatic cancer with monoclonal antibody BW 494
Immunotherapy of pancreatic cancer with monoclonal antibody BW 494
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单克隆抗体 BW 494 的胰腺癌免疫治疗
DOI：
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
K. Bosslet
中科院分区：
文献类型：
--
作者：
G. Schulz;M. Büchler;K. Muhrer;R. Klapdor;R. Kübel;H. Harthus;N. Madry;K. Bosslet
In a phase I trial 34 patients with pancreatic cancer were treated with the murine monoclonal antibody (MAb) BW 494 (BI 51.011) directed against a glycoprotein antigen. The patients received repeated doses of MAb over a time period from 5 to 14 days (highest single dose 100 mg, highest cumulative dose 490 mg). During this treatment serum levels of murine lgG increased to 43.4 μg/ml. The serum half life of murine lgG ranged from 2 to 3 days. Repeated injections of MAb BW 494 were normally well‐tolerated when given within the first 15 days. Two patients presented with fatigue and a neuritis‐like syndrome 2 weeks after the last lgG infusion which had resolved spontaneously by the next day. Severe allergic reactions were observed in 3 patients after repeated injections of the MAb. These 3 patients had high levels of human anti‐murine antibodies (HAMA). Four weeks after the first application of MAb BW 494, 17/18 patients presented with HAMA (lgG). It could be demonstrated that the anti‐murine response was in part anti‐idiotypic. At the moment 16/34 patients are eligible for evaluation of tumor response. There was no complete or partial remission; however, 2 patients responded with minor tumor regression up to 32 weeks documented by reduction of liver metastases and primary tumor in CAT scan. Five additional patients presented with a long period of stable disease after immunotherapy (up to 40 weeks). Nine patients had progressive tumor disease in spite of MAb treatment.
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DOI：
10.1016/s0021-9258(19)45389-1
发表时间：
1982-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
通讯作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
癌症患者中的人类抗独特型抗体：免疫反应的调节对患者有益吗？
DOI：
10.1073/pnas.81.1.216
发表时间：
1984
影响因子：
11.1
作者：
Koprowski,H;Herlyn,D;Lubeck,M;DeFreitas,E;Sears,HF
通讯作者：
Sears,HF
影响因子：
11.2
作者：
J. Magnani;Z. Steplewski;H. Koprowski;V. Ginsburg
通讯作者：
J. Magnani;Z. Steplewski;H. Koprowski;V. Ginsburg
DOI：
10.1073/pnas.79.15.4761
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HERLYN, D;KOPROWSKI, H
通讯作者：
KOPROWSKI, H
鼠单克隆抗体细胞毒性胃肠道腺癌的 II 期临床试验。
影响因子：
11.2
作者：
Sears,HF;Herlyn,D;Steplewski,Z;Koprowski,H
通讯作者：
Koprowski,H