Declining genital Warts in young women in england associated with HPV 16/18 vaccination: an ecological study.
Declining genital Warts in young women in england associated with HPV 16/18 vaccination: an ecological study.
复制标题
与HPV 16/18疫苗接种相关的英格兰年轻女性的生殖器疣下降：一项生态研究。
DOI：
10.1093/infdis/jit361
复制
发表时间：
2013-11-01
期刊：
影响因子：
--
通讯作者：
Hughes G
中科院分区：
文献类型：
--
作者：
Howell-Jones R;Soldan K;Wetten S;Mesher D;Williams T;Gill ON;Hughes G
背景。 多年来，英国泌尿生殖医学 (GUM) 诊所对尖锐湿疣 (GW) 的诊断数量一直在增加。 2008 年，HPV 免疫计划开始使用二价疫苗 (Cervarix)。预计这将显着减少人乳头瘤病毒 (HPV) 16/18 引起的感染和疾病，但不会减少 HPV 6/11 感染或疾病。然而，从 2009 年到 2011 年，GUM 诊所报告的年轻女性 GW 诊断数量有所减少。方法。 我们利用 GUM 诊所的数据和全英格兰全科医生 (GP) 的样本，按年龄、诊断年份和估计免疫覆盖率分析了 GW 诊断率。结果。 2008 年至 2011 年间，GUM 诊所 16 至 19 岁女性的 GW 诊断总体下降了 13.3%，其中 17 岁女性降幅最大，达到 20.8%。下降与估计的免疫覆盖率呈正相关。在全科医生的诊断中也发现了类似的模式，但在老年女性中以及其他古姆医学会诊中却没有。结论。 有几个因素可能导致 GW 下降。然而，下降的规模和模式强烈表明，我们正在观察 HPV 16/18 疫苗接种对 GW 的意外、适度的保护作用。
Background. Diagnoses of genital warts (GW) in genitourinary medicine (GUM) clinics have been increasing in England for many years. In 2008, an HPV immunization program began with a bivalent vaccine (Cervarix). This was expected to markedly reduce infections and disease due to human papillomavirus (HPV) 16/18 but not HPV 6/11 infections or disease. However, from 2009 to 2011 there were decreases in reported diagnoses of GW in young females at GUM clinics. Methods. Using data from GUM clinics and a sample of general practices (GPs) throughout England, we analyzed rates of GW diagnoses by age, year of diagnosis, and estimated immunization coverage. Results. The overall reduction in GW diagnoses at GUM clinics between 2008 and 2011 was 13.3% among 16- to 19-year-old females, with the greatest decline of 20.8% in 17-year-olds. Declines were positively associated with estimated immunization coverage. A similar pattern was seen in GP diagnoses, but not among older women, and for other GUM consultations. Conclusions. Several factors might contribute to declines in GW. However, the size and pattern of the declines strongly suggest that we are observing an unexpected, moderately protective effect of HPV 16/18 vaccination against GW.
登录
查看更多内容
影响因子：
5.5
作者：
Forster, Alice S.;Marlow, Laura A. V.;Waller, Jo
通讯作者：
Waller, Jo
影响因子：
3.6
作者：
Hughes, G;Catchpole, M;Thin, N
通讯作者：
Thin, N
影响因子：
105.7
作者：
Jit, Mark;Choi, Yoon Hong;Edmunds, W. John
通讯作者：
Edmunds, W. John
影响因子：
12.7
作者：
Ball, Siolian L. R.;Winder, David M.;Goon, Peter K. C.
通讯作者：
Goon, Peter K. C.
HPV-16/18 AS04辅助疫苗对低风险HPV类型（Patricia随机试验）的功效：意外观察。
DOI：
10.1093/infdis/jit360
发表时间：
2013-11-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Szarewski A;Skinner SR;Garland SM;Romanowski B;Schwarz TF;Apter D;Chow SN;Paavonen J;Del Rosario-Raymundo MR;Teixeira JC;De Carvalho NS;Castro-Sanchez M;Castellsagué X;Poppe WA;De Sutter P;Huh W;Chatterjee A;Tjalma WA;Ackerman RT;Martens M;Papp KA;Bajo-Arenas J;Harper DM;Torné A;David MP;Struyf F;Lehtinen M;Dubin G
通讯作者：
Dubin G