Current and future developments in the treatment of virus-induced hypercytokinemia.
Current and future developments in the treatment of virus-induced hypercytokinemia.
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DOI：
10.4155/fmc-2016-0181
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发表时间：
2017-03
影响因子：
4.2
通讯作者：
D'Elia RV
中科院分区：
文献类型：
--
作者：
Wong JP;Viswanathan S;Wang M;Sun LQ;Clark GC;D'Elia RV
新出现的致病性病毒，如埃博拉病毒和中东呼吸综合征冠状病毒（MERS-CoV），可通过逃避宿主的抗病毒免疫反应和诱导炎症细胞因子的上调，引起急性感染。这种免疫失调，称为细胞因子风暴或高细胞因子血症，具有潜在的致命性，是感染患者死亡率增加的重要潜在因素。近年来全球疫情的流行为研究各种病毒感染的进展提供了机会，并提供了对与这些疾病相关的高细胞分裂血症的更好理解。然而，尽管对一系列新出现的病毒引起的感染的了解和研究有所增加，但治疗选择仍然有限。本综述旨在探讨治疗埃博拉病毒、禽流感和登革热病毒引起的高细胞分裂血症的替代实验策略；概述其作用方式，总结其临床前评估和潜在的临床应用。
Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.
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影响因子：
--
作者：
Castro JE;Vado-Solis I;Perez-Osorio C;Fredeking TM
通讯作者：
Fredeking TM
影响因子：
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作者：
Oldstone MB;Rosen H
通讯作者：
Rosen H
影响因子：
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作者：
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Schmidt-Chanasit J
影响因子：
64.8
作者：
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通讯作者：
Katze, Michael G.
影响因子：
4.8
作者：
Nash, P;Whitty, A;McFadden, G
通讯作者：
McFadden, G