Small-molecule inhibitors of myosin proteins.
Small-molecule inhibitors of myosin proteins.
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DOI：
10.4155/fmc.12.185
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发表时间：
2013-01
影响因子：
4.2
通讯作者：
Buss F
中科院分区：
文献类型：
--
作者：
Bond LM;Tumbarello DA;Kendrick-Jones J;Buss F
Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular processes, from intracellular trafficking to cell motility, and are implicated in several human diseases (e.g., cancer, hypertrophic cardiomyopathy, deafness and many neurological disorders). Potent and selective myosin inhibitors are, therefore, not only a tool for understanding myosin function, but are also a resource for developing treatments for diseases involving myosin dysfunction or overactivity. This review will provide a brief overview of the characteristics and scientific/therapeutic applications of the presently identified small-molecule myosin inhibitors before discussing the future of myosin inhibitor and activator design.
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DOI：
10.1083/jcb.201201024
发表时间：
2012-07-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Eves PT;Jin Y;Brunner M;Weisman LS
通讯作者：
Weisman LS
影响因子：
5.5
作者：
Fedorov, Vadim V.;Lozinsky, Ilya T.;Efimov, Igor R.
通讯作者：
Efimov, Igor R.
影响因子：
2
作者：
Gavin, Cristin F.;Rubio, Maria D.;Rumbaugh, Gavin
通讯作者：
Rumbaugh, Gavin
影响因子：
4.8
作者：
Chinthalapudi, Krishna;Taft, Manuel H.;Manstein, Dietmar J.
通讯作者：
Manstein, Dietmar J.
影响因子：
3.3
作者：
Berg, JS;Powell, BC;Cheney, RE
通讯作者：
Cheney, RE