The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9.
The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9.
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通过激活NRF2和MMP-9的抑制，类黄酮在白内障形成中的保护作用。
DOI：
10.3390/nu12123651
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发表时间：
2020-11-27
期刊：
影响因子：
5.9
通讯作者：
Soliman KFA
中科院分区：
文献类型：
--
作者：
Hilliard A;Mendonca P;Russell TD;Soliman KFA
白内障占全球失明人数的一半以上。白内障的形成主要是由于衰老以及氧化应激和炎症对眼晶状体的直接损害。核因子红细胞 2 相关因子 2 (Nrf2) 是一种细胞保护转录因子，被称为氧化还原稳态的主要调节因子。 Nrf2 调节近 600 个基因，这些基因参与细胞保护，抵抗氧化应激的影响因素，包括衰老、疾病和炎症。据报道，Nrf2 可以破坏激活核因子-κB (NFκB) 和促炎细胞因子的氧化应激。其中一种细胞因子是基质金属蛋白酶 9 (MMP-9)，它参与晶状体上皮细胞 (LEC) 细胞外基质的分解，并与白内障的发展相关。因此，在炎症过程中，MMP 的产生可能通过 Nrf2 途径或通过 Nrf2 抑制 NFκB 途径激活而减弱。此外，植物多酚因其假定的安全性和功效、营养和抗氧化作用而引起了人们的关注。多酚类化合物可以激活Nrf2并抑制MMP-9。因此，本综述重点讨论Nrf2在氧化应激和白内障形成中的作用、Nrf2活性的表观遗传效应以及Nrf2和MMP-9在白内障发生中的关联。此外，我们描述了类黄酮在白内障形成中的保护作用，将 Nrf2 激活和 MMP-9 合成抑制作为预防白内障的潜在分子靶点。
Cataracts account for over half of global blindness. Cataracts formations occur mainly due to aging and to the direct insults of oxidative stress and inflammation to the eye lens. The nuclear factor-erythroid-2-related factor 2 (Nrf2), a transcriptional factor for cell cytoprotection, is known as the master regulator of redox homeostasis. Nrf2 regulates nearly 600 genes involved in cellular protection against contributing factors of oxidative stress, including aging, disease, and inflammation. Nrf2 was reported to disrupt the oxidative stress that activates Nuclear factor-κB (NFκB) and proinflammatory cytokines. One of these cytokines is matrix metalloproteinase 9 (MMP-9), which participates in the decomposition of lens epithelial cells (LECs) extracellular matrix and has been correlated with cataract development. Thus, during inflammatory processes, MMP production may be attenuated by the Nrf2 pathway or by the Nrf2 inhibition of NFκB pathway activation. Moreover, plant-based polyphenols have garnered attention due to their presumed safety and efficacy, nutritional, and antioxidant effects. Polyphenol compounds can activate Nrf2 and inhibit MMP-9. Therefore, this review focuses on discussing Nrf2’s role in oxidative stress and cataract formation, epigenetic effect in Nrf2 activity, and the association between Nrf2 and MMP-9 in cataract development. Moreover, we describe the protective role of flavonoids in cataract formation, targeting Nrf2 activation and MMP-9 synthesis inhibition as potential molecular targets in preventing cataracts.
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影响因子：
--
作者：
Batliwala S;Xavier C;Liu Y;Wu H;Pang IH
通讯作者：
Pang IH
DOI：
10.1016/j.biocel.2008.06.010
发表时间：
2009-01
影响因子：
4
作者：
Aggarwal, Bharat B.;Harikumar, Kuzhuvelil B.
通讯作者：
Harikumar, Kuzhuvelil B.
影响因子：
2
作者：
Cao, Jing;Wang, Tao;Wang, Meng
通讯作者：
Wang, Meng
影响因子：
1.7
作者：
Chang, P. Y.;Bjornstad, K. A.;Blakely, E. A.
通讯作者：
Blakely, E. A.
DOI：
10.1073/pnas.82.21.7193
发表时间：
1985-01-01
影响因子：
11.1
作者：
BENSCH, KG;FLEMING, JE;LOHMANN, W
通讯作者：
LOHMANN, W