Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study.
Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study.
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重度抑郁症中丘脑和初级体感皮层之间的功能连接：静息态功能磁共振成像研究
DOI：
10.1186/s12888-018-1913-6
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发表时间：
2018-10-19
期刊：
影响因子：
4.4
通讯作者：
Zhang K
中科院分区：
文献类型：
--
作者：
Kang L;Zhang A;Sun N;Liu P;Yang C;Li G;Liu Z;Wang Y;Zhang K
研究已经证实，丘脑和初级体感皮层（SI）与认知功能有关。这两个脑区在结构和功能上密切相关。SI与丘脑的相互作用对认知过程具有至关重要的意义。重度抑郁症（MDD）患者有明显的认知障碍。基于这些观察，我们使用静息状态功能磁共振成像（rs-fMRI）来研究MDD中si -丘脑功能连接是否存在异常。此外，我们还探讨了与这种异常相关的临床症状。方法纳入31例首发重性抑郁症患者和28例年龄、性别和教育程度相匹配的健康对照（HC）。比较MDD组和HC组si -丘脑功能连通性。对连接异常区域与临床特征进行相关性分析。结果与健康受试者相比，MDD患者丘脑与SI之间的功能连通性增强（p< 0.05，校正）。MDD患者神经心理状态评估总分（r= - 0.383,p= 0.033）、延迟记忆评分（r= - 0.376,p= 0.037）、两位数连续操作测试评分（r= - 0.369,p= 0.041）与脑连通性水平显著不同的脑区呈负相关。结论si -丘脑功能连接异常，与重度抑郁症的核心临床症状有关。si -丘脑功能连通性是MDD的神经生物学特征和潜在的生物标志物。
BackgroundStudies have confirmed that the thalamus and the primary somatosensory cortex (SI) are associated with cognitive function. These two brain regions are closely related in structure and function. The interactions between SI and the thalamus are of crucial significance for the cognitive process. Patients with major depressive disorder (MDD) have significant cognitive impairment. Based on these observations, we used resting-state functional magnetic resonance imaging (rs-fMRI) to investigate whether there is an abnormality in the SI-thalamic functional connection in MDD. Furthermore, we explored the clinical symptoms related to this abnormality.MethodsWe included 31 patients with first-episode major depressive disorder and 28 age-, gender-, and education-matched healthy controls (HC). The SI-thalamic functional connectivity was compared between the MDD and HC groups. The correlation analyses were performed between areas with abnormal connectivity and clinical characteristics.ResultsCompared with healthy subjects, the MDD patients had enhanced functional connectivity between the thalamus and SI (p< 0.05, corrected). Brain areas with significantly different levels of connectivity had a negative correlation with the Assessment of Neuropsychological Status total score (r= − 0.383,p= 0.033), delayed memory score (r= − 0.376,p= 0.037) and two-digit continuous operation test score (r= − 0.369,p= 0.041) in MDD patients.ConclusionsThese results demonstrate that SI-thalamic functional connectivity is abnormal and associated with the core clinical symptoms in MDD. The SI-thalamic functional connectivity functions as a neurobiological feature and potential biomarker for MDD.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1177/1352458518760716
发表时间：
2019-04
期刊：
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影响因子：
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作者：
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通讯作者：
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