Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study.
Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study.
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DOI：
10.1111/j.1469-7610.2010.02205.x
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Eaves LJ
中科院分区：
文献类型：
--
作者：
Silberg JL;Maes H;Eaves LJ
尽管抑郁父母的孩子患抑郁症和行为问题的风险增加，但父母抑郁症影响孩子行为和情感功能的机制还不清楚。本研究旨在确定父母抑郁是否代表儿童精神病理学中的一个真正的环境风险因素，或者儿童抑郁/行为是否可以解释为从父母传递给后代的遗传责任的次要后果。研究人员收集了2,674名成年女性和男性双胞胎及其配偶和2,940名子女的双胞胎子女（COT）数据，以探讨遗传和/或家庭环境因素是否最能解释父母抑郁症与子女抑郁症和行为问题之间的关联。从青少年行为发展的弗吉尼亚双胞胎研究（VTSABD）收集的数据也包括估计儿童特定的遗传和环境的影响，除了从父母抑郁症本身的传输所产生的影响。使用统计程序Mx评估替代双胞胎模型的拟合。父母和青少年抑郁症之间最令人信服的关联模型是直接环境风险模型。父母抑郁与子女品行障碍的关系受家庭环境因素和遗传因素的影响。这些发现说明了遗传介导的行为，如父母的抑郁症，如何对儿童的行为产生环境和遗传影响。我们发现发育特定的遗传因素是青少年和成人抑郁症风险的基础。一个共同的遗传易感性影响父母抑郁症和青少年行为障碍，暗示儿童CD作为一个早期指标的遗传风险抑郁症在成年期。总之，我们的分析表明，父母抑郁对不同形式的儿童精神病理学的影响存在差异，并在不同的发展阶段。
Despite the increased risk of depression and conduct problems in children of depressed parents, the mechanism by which parental depression affects their children’s behavioral and emotional functioning is not well understood. The present study was undertaken to determine whether parental depression represents a genuine environmental risk factor in children’s psychopathology, or whether children’s depression/conduct can be explained as a secondary consequence of the genetic liability transmitted from parents to their offspring. Children of Twins (COT) data collected on 2,674 adult female and male twins, their spouses, and 2,940 of their children were used to address whether genetic and/or family environmental factors best account for the association between depression in parents and depression and conduct problems in their children. Data collected on juvenile twins from the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) were also included to estimate child-specific genetic and environmental influences apart from those effects arising from the transmission of the parental depression itself. The fit of alternative Children of Twin models were evaluated using the statistical program Mx. The most compelling model for the association between parental and juvenile depression was a model of direct environmental risk. Both family environmental and genetic factors accounted for the association between parental depression and child conduct disturbance. These findings illustrate how a genetically mediated behavior such as parental depression can have both an environmental and genetic impact on children’s behavior. We find developmentally specific genetic factors underlying risk to juvenile and adult depression. A shared genetic liability influence both parental depression and juvenile conduct disturbance, implicating child CD as an early indicator of genetic risk for depression in adulthood. In summary, our analyses demonstrate differences in the impact of parental depression on different forms of child psychopathology, and at various stages of development.
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DOI：
10.1111/j.1469-7610.2004.00367.x
发表时间：
2005-05-01
影响因子：
7.6
作者：
Burt, KB;Van Dulmen, MHM;Carlson, EA
通讯作者：
Carlson, EA
DOI：
10.1111/1469-7610.00196
发表时间：
2003-11-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
D'Onofrio, BM;Turkheimer, EN;Emery, RE
通讯作者：
Emery, RE
影响因子：
0.9
作者：
Medland, Sarah E.;Keller, Matthew C.
通讯作者：
Keller, Matthew C.
影响因子：
2.4
作者：
Fonagy, P
通讯作者：
Fonagy, P
DOI：
10.1375/twin.12.1.26
发表时间：
2009-02
期刊：
Twin research and human genetics : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Maes HH;Neale MC;Medland SE;Keller MC;Martin NG;Heath AC;Eaves LJ
通讯作者：
Eaves LJ