Impacts of environmental toxicants on male reproductive dysfunction.
Impacts of environmental toxicants on male reproductive dysfunction.
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DOI：
10.1016/j.tips.2011.01.001
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发表时间：
2011-05
影响因子：
13.8
通讯作者：
Cheng CY
中科院分区：
文献类型：
--
作者：
Wong EW;Cheng CY
由镉、汞、双酚A(BPA)和二恶英等环境毒物引起的男性不育是一个全球性问题，在工业化国家尤其如此。对睾丸和其他器官的研究表明，环境毒物诱导的氧化应激在调节细胞连接中断方面的重要性。这反过来又受PI3K/c-Src/FAK和MAPK信号通路的激活调控，涉及极性蛋白，导致生殖功能障碍，如男性精子数量减少和精液质量下降。在这篇综述中，我们讨论了这些发现如何提高对环境毒物在睾丸功能障碍中的作用模式的理解。因此，针对这些途径中的信号分子的特定抑制剂和/或拮抗剂可能逆转和/或阻断毒物诱导的损伤的破坏效应。还需要更多比较高水平急性暴露和低水平慢性暴露环境毒物的研究，以充分阐明这些毒物扰乱男性生殖功能的潜在分子机制(S)。
Male infertility caused by exposure to environmental toxicants, such as cadmium, mercury, bisphenol A (BPA) and dioxin, is a global problem, particularly in industrialized countries. Studies in the testis and other organs have illustrated the importance of environmental toxicant-induced oxidative stress in mediating disruption to cell junctions. This, in turn, is regulated by the activation of PI3K/c-Src/FAK and MAPK signaling pathways, with the involvement of polarity proteins, leading to reproductive dysfunction, such as reduced sperm count and semen quality in men. In this review, we discuss how these findings can improve understanding of the modes of action of environmental toxicants in –testicular dysfunction. Thus, specific inhibitors and/or antagonists against signaling molecules in these pathways can possibly reverse and/or block the disruptive effects of toxicant-induced damage. Additional studies comparing high level acute exposure versus low level chronic exposure to environmental toxicants are also needed to elucidate fully the underlying molecular mechanism(s) by which these toxicants disrupt male reproductive function.
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DOI：
10.1038/nrendo.2010.71
发表时间：
2010-07
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.1
作者：
Almog, Tal;Naor, Zvi
通讯作者：
Naor, Zvi
影响因子：
3.3
作者：
Acharya, Usha R.;Mishra, Monalisa;Panda, Manoj K.
通讯作者：
Panda, Manoj K.
影响因子：
64.8
作者：
Aitken, RJ;Koopman, P;Lewis, SEM
通讯作者：
Lewis, SEM
影响因子：
7.4
作者：
Chen, Long;Liu, Lei;Huang, Shile
通讯作者：
Huang, Shile