The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China.
The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China.
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DOI：
10.3389/fvets.2021.687079
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发表时间：
2021
影响因子：
3.2
通讯作者：
Xing L
中科院分区：
文献类型：
--
作者：
Guo YY;Wang PH;Pan YQ;Shi RZ;Li YQ;Guo F;Xing L
猪急性腹泻综合征（SADS）是一种以新生仔猪急性呕吐和水样腹泻为特征的高度接触性传染病。SADS的病原体是猪急性腹泻综合征冠状病毒（SADS-CoV），一种冠状病毒科的猪冠状病毒。目前，SADS-CoV仅在中国广东省和福建省发现，在世界其他地区或国家尚未发现。为了探索SADS-CoV分离株的遗传多样性，本文比较分析了2017-2019年期间在广东和福建省分离的44种病毒的全长基因组。SADS-CoV福建分离株CH/FJWT/2018的纤突蛋白基因无论是基于纤突蛋白基因的系统发育分析，还是基于全基因组的基因相似性分析，均与其他病毒分离株不同。此外，与广东省代表性病毒分离株相比，CH/FJWT/2018的刺突糖蛋白中至少有7个预测的线性B细胞表位会受到氨基酸变异的影响。冠状病毒的刺突糖蛋白通过与细胞受体的特异性相互作用决定病毒感染期间的病毒宿主范围和组织嗜性，并且还在引发中和抗体的产生中起关键作用。由于SADS-CoV具有广泛的细胞嗜性，本报告的结果进一步强调了刺突糖蛋白基因是SADS-CoV监测的关键靶标。
Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets. The causative agent for SADS is the swine acute diarrhea syndrome coronavirus (SADS-CoV), an alphacoronavirus in the family Coronaviridae. Currently, SADS-CoV was identified only in Guangdong and Fujian provinces of China, not in any other regions or countries in the world. To explore the genetic diversity of SADS-CoV isolates, herein we comparatively analyzed 44 full-length genomes of viruses isolated in Guangdong and Fujian provinces during 2017–2019. The spike glycoprotein gene of SADS-CoV strain CH/FJWT/2018 isolated in Fujian province is distinct from that of other viral isolates in either spike glycoprotein gene-based phylogenetic analysis or whole genome-based gene similarity analysis. Moreover, at least 7 predicted linear B cell epitopes in the spike glycoprotein of CH/FJWT/2018 would be affected by amino acid variations when compared with a representative virus isolated in Guangdong province. The spike glycoprotein of coronaviruses determines viral host range and tissue tropism during virus infection via specific interactions with the cellular receptor and also plays critical roles in eliciting the production of neutralizing antibodies. Since SADS-CoVs have a broad cell tropism, the results in this report further emphasize that the spike glycoprotein gene is a pivotal target in the surveillance of SADS-CoV.
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影响因子：
11.8
作者：
Gong L;Li J;Zhou Q;Xu Z;Chen L;Zhang Y;Xue C;Wen Z;Cao Y
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作者：
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影响因子：
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作者：
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DOI：
10.3390/v6082991
发表时间：
2014-08-07
期刊：
Viruses
影响因子：
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作者：
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通讯作者：
Fielding BC