Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women.
Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women.
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DOI：
10.1136/sti.2008.035451
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发表时间：
2009-09
影响因子：
3.6
通讯作者：
McClelland RS
中科院分区：
文献类型：
--
作者：
Baeten JM;Hassan WM;Chohan V;Richardson BA;Mandaliya K;Ndinya-Achola JO;Jaoko W;McClelland RS
乳酸菌在阴道定植是正常阴道生态的特征。阴道乳杆菌，特别是产生过氧化氢 (H2O2) 的分离株的缺乏，与症状性细菌性阴道病 (BV) 和感染 HIV-1 的风险增加有关。鉴定与阴道乳酸杆菌定植相关的因素可能会建议采取干预措施来改善阴道健康。我们对肯尼亚 HIV-1 血清阴性女性性工作者中阴道乳酸杆菌定植的相关性进行了一项前瞻性队列研究。在每月的随访中，获得阴道乳酸杆菌培养物。使用广义估计方程来检查乳酸菌分离的人口统计学、行为和医学相关性，包括产生 H2O2 的菌株的分离。从 1020 名女性身上获得了乳酸菌培养物，这些女性总共完成了 8896 次随访。阴道清洗（通常仅用水或用肥皂和水）与乳杆菌分离（包括产生 H2O2 菌株的分离）的可能性降低约 40% 相关。最近的抗生素使用（不包括甲硝唑和阴道念珠菌病治疗）导致乳酸菌分离量减少约 30%。在患有阴道毛滴虫感染和 2 型单纯疱疹病毒血清阳性的女性中，产生 H2O2 的乳杆菌明显较少见。相比之下，在并发阴道念珠菌病的女性中，产生 H2O2 的乳杆菌明显更常见。可改变的生物和行为因素与非洲女性体内乳酸菌的定植有关。我们的研究结果提出了改善 HIV-1 高危女性阴道健康的干预策略。
Vaginal colonization with Lactobacillus species is characteristic of normal vaginal ecology. The absence of vaginal lactobacilli, particularly hydrogen peroxide (H2O2)-producing isolates, has been associated with symptomatic bacterial vaginosis (BV) and increased risk for HIV-1 acquisition. Identification of factors associated with vaginal Lactobacillus colonization may suggest interventions to improve vaginal health. We conducted a prospective cohort study of correlates of vaginal Lactobacillus colonization among Kenyan HIV-1 seronegative female sex workers. At monthly follow-up visits, vaginal Lactobacillus cultures were obtained. Generalized estimating equations were used to examine demographic, behavioral, and medical correlates of Lactobacillus isolation, including isolation of H2O2-producing strains. Lactobacillus cultures were obtained from 1020 women who completed a total of 8896 follow-up visits. Vaginal washing, typically with water alone or with soap and water, was associated with an approximately 40% decreased likelihood of Lactobacillus isolation, including isolation of H2O2-producing strains. Recent antibiotic use, excluding metronidazole and treatments for vaginal candidiasis, reduced Lactobacillus isolation by ~30%. H2O2-producing lactobacilli were significantly less common among women with Trichomonas vaginalis infection and those who were seropositive for herpes simplex virus type 2. In contrast, H2O2-producing lactobacilli were significantly more common among women with concurrent vaginal candidiasis. Modifiable biologic and behavioral factors are associated with Lactobacillus colonization in African women. Our results suggest intervention strategies to improve vaginal health in women at high risk for HIV-1.
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影响因子：
6.4
作者：
Torok, Michelle R.;Miller, William C.;Sena, Arlene C.
通讯作者：
Sena, Arlene C.
DOI：
10.1097/qai.0b013e3181743936
发表时间：
2008-06-01
影响因子：
3.6
作者：
van de Wijgert, Danneke H. H. M.;Morrison, Charles S.;Padian, Nancy S.
通讯作者：
Padian, Nancy S.
影响因子：
6.4
作者：
KLEBANOFF, SJ;HILLIER, SL;WALTERSDORPH, AM
通讯作者：
WALTERSDORPH, AM
影响因子：
6.4
作者：
Martin, HL;Richardson, BA;Kreiss, J
通讯作者：
Kreiss, J
影响因子：
3.1
作者：
Cherpes, Thomas L.;Hillier, Sharon L.;Krohn, Marijane A.
通讯作者：
Krohn, Marijane A.