Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
复制标题
DOI：
10.1371/journal.pone.0028668
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Steardo L
中科院分区：
文献类型：
--
作者：
Esposito G;Scuderi C;Valenza M;Togna GI;Latina V;De Filippis D;Cipriano M;Carratù MR;Iuvone T;Steardo L
据报道，过氧化物酶体增殖物激活受体-γ (PPARγ) 参与阿尔茨海默病 (AD) 病理特征的病因学。大麻二酚 (CBD) 是一种没有拟心理作用的大麻衍生物，因其在大鼠 AD 模型中具有良好的神经保护特性而备受关注，尽管这种作用的机制仍不清楚。这项研究旨在探索 CBD 的效应是否可能服从于其在 PPARγ 上的活性，最近已表明 PPARγ 是其假定的结合位点。研究了在存在或不存在 PPAR 拮抗剂的情况下 CBD 对大鼠 AD 模型中 β-淀粉样蛋白诱导的神经毒性的作用。结果表明，PPARγ 的阻断能够显着减弱 CBD 对反应性神经胶质增生以及随后对神经元损伤的影响。此外，由于 CBD 与 PPARγ 的相互作用，观察到 CBD 可以刺激海马神经发生。所有这些发现都报告了这种受体在介导 CBD 作用中不可避免的作用，这里报道。
Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at exploring whether CBD effects could be subordinate to its activity at PPARγ, which has been recently indicated as its putative binding site. CBD actions on β-amyloid-induced neurotoxicity in rat AD models, either in presence or absence of PPAR antagonists were investigated. Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage. Moreover, due to its interaction at PPARγ, CBD was observed to stimulate hippocampal neurogenesis. All these findings report the inescapable role of this receptor in mediating CBD actions, here reported.
登录
查看更多内容
DOI：
10.2174/1568010053586237
发表时间：
2005-04-05
期刊：
Current Drug Targets - Inflammation and Allergy
影响因子：
--
作者：
Ho, Gilbert J.;Drego, Roulla;Masliah, Eliezer
通讯作者：
Masliah, Eliezer
影响因子：
2.5
作者：
Miglio, Gianluca;Rattazzi, Lorenza;Fantozzi, Roberto
通讯作者：
Fantozzi, Roberto
影响因子：
2.9
作者：
Bright, John J.;Kanakasabai, Saravanan;Chearwae, Wanida;Chakraborty, Sharmistha
通讯作者：
Chakraborty, Sharmistha
影响因子：
25.7
作者：
Magen, Iddo;Avraham, Yosefa;Berry, Elliot M.
通讯作者：
Berry, Elliot M.
影响因子：
64.5
作者：
Bookout, Angie L.;Jeong, Yangsik;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.