Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma.
Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma.
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MACC1 鉴定为肝细胞癌的新型预后标志物
DOI：
10.1186/1479-5876-9-166
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发表时间：
2011-09-29
影响因子：
7.4
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Qiu J;Huang P;Liu Q;Hong J;Li B;Lu C;Wang L;Wang J;Yuan Y
背景
结肠癌转移相关基因 1 (MACC1) 是一种新发现的基因，通过上调 c-MET 原癌基因 (c-MET) 在结肠癌转移中发挥作用。然而，MACC1 作为肝细胞癌 (HCC) 潜在生物标志物的价值仍不清楚。
方法
通过定量聚合酶链反应检测 128 个 HCC 组织中 MACC1 mRNA 的表达。为了显示 MACC1 和 c-MET 的潜在相关性，还对 c-MET 进行了分析。
结果
MACC1 在 HCC 组织中的表达量高于非 HCC 组织 (P = 0.009)。在甲胎蛋白 (AFP) 高的病例中，MACC1 的高表达显着增加 (P = 0.025)。 MACC1 和 c-MET mRNA 之间存在正相关（r = 0.235，P = 0.009）。单变量和多变量分析均显示 MACC1 表达与总生存期 (OS) 和无病生存期 (DFS) 相关。此外，分层分析显示，MACC1 水平高的肿瘤淋巴结转移 (TNM) I 期患者比 MACC1 水平低的患者具有更短的 OS 和 DFS。
结论
MACC1可以识别患有HCC的低风险和高风险个体，并且是对TNM I期患者的预后进行分层的有价值的指标。 MACC1 可能作为 HCC 的新型生物标志物。
Background
Metastasis-associated in colon cancer-1 (MACC1) is a newly identified gene that plays a role in colon cancer metastasis through upregulation of c-MET proto-oncogene (c-MET). However, the value of MACC1 as a potential biomarker for hepatocellular carcinoma (HCC) remains unknown.
Methods
MACC1 mRNA expression in 128 HCC tissues was examined by quantitative polymerase chain reaction. To show the potential correlation of MACC1 and c-MET, c-MET was also analysed.
Results
MACC1 was more highly expressed in HCC than in non-HCC tissues (P = 0.009). High MACC1 expression was significantly increased in cases with high alpha fetoprotein (AFP) (P = 0.025). A positive correlation was found between MACC1 and c-MET mRNAs (r = 0.235, P = 0.009). Both univariate and multivariate analyses revealed that MACC1 expression was associated with overall survival (OS) and disease-free survival (DFS). Moreover, stratified analysis showed that tumour-node-metastasis (TNM) stage I patients with high MACC1 levels had shorter OS and DFS than those with low MACC1.
Conclusions
MACC1 may identify low- and high-risk individuals with HCC and be a valuable indicator for stratifying the prognosis of TNM stage I patients. MACC1 may serve as a novel biomarker for HCC.
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