Amyloid-β associated cortical thinning in clinically normal elderly.
Amyloid-β associated cortical thinning in clinically normal elderly.
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DOI：
10.1002/ana.22333
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发表时间：
2011-06
影响因子：
11.2
通讯作者：
Johnson, Keith A.
中科院分区：
文献类型：
--
作者：
Becker, J. Alex;Hedden, Trey;Carmasin, Jeremy;Maye, Jacqueline;Rentz, Dorene M.;Putcha, Deepti;Fischl, Bruce;Greve, Douglas N.;Marshall, Gad A.;Salloway, Stephen;Marks, Donald;Buckner, Randy L.;Sperling, Reisa A.;Johnson, Keith A.
淀粉样蛋白-β（Aβ）沉积和脑萎缩都与阿尔茨海默病（AD）有关，并且疾病过程可能在症状出现前多年就开始了。我们试图确定使用匹兹堡化合物B（Pi B）进行正电子发射断层扫描（PET）成像显示的Aβ沉积的临床正常（CN）老年人是否也有皮质厚度和海马体积减少的证据，其模式与AD相似。共有119名老年人（87名CN受试者和32名轻度AD患者）接受了PiB PET和高分辨率结构磁共振成像（MRI）。使用回归模型将PiB保留与皮质厚度和海马体积相关。我们发现CN受试者的PiB保留（1）与年龄相关，（2）与皮质厚度减少相关，特别是在延伸到楔前叶的顶叶和后扣带回区域，其模式与轻度AD中观察到的模式相似。海马体积减少与Aβ沉积呈负相关。我们得出的结论是，Aβ沉积与认知障碍发生之前AD的皮质厚度减少模式一致。ANN神经元2010;
Both amyloid-β (Aβ) deposition and brain atrophy are associated with Alzheimer's disease (AD) and the disease process likely begins many years before symptoms appear. We sought to determine whether clinically normal (CN) older individuals with Aβ deposition revealed by positron emission tomography (PET) imaging using Pittsburgh Compound B (PiB) also have evidence of both cortical thickness and hippocampal volume reductions in a pattern similar to that seen in AD. A total of 119 older individuals (87 CN subjects and 32 patients with mild AD) underwent PiB PET and high-resolution structural magnetic resonance imaging (MRI). Regression models were used to relate PiB retention to cortical thickness and hippocampal volume. We found that PiB retention in CN subjects was (1) age-related and (2) associated with cortical thickness reductions, particularly in parietal and posterior cingulate regions extending into the precuneus, in a pattern similar to that observed in mild AD. Hippocampal volume reduction was variably related to Aβ deposition. We conclude that Aβ deposition is associated with a pattern of cortical thickness reduction consistent with AD prior to the development of cognitive impairment. ANN NEUROL 2010;
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1093/brain/awp123
发表时间：
2009-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Desikan RS;Cabral HJ;Hess CP;Dillon WP;Glastonbury CM;Weiner MW;Schmansky NJ;Greve DN;Salat DH;Buckner RL;Fischl B;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
5.7
作者：
Daselaar, SM;Prince, SE;Cabeza, R
通讯作者：
Cabeza, R
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
影响因子：
38.1
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
通讯作者：
Thompson, Paul M.