Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
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DOI：
10.1371/journal.pone.0027694
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Lim S
中科院分区：
文献类型：
--
作者：
Kang SM;Yoon JW;Ahn HY;Kim SY;Lee KH;Shin H;Choi SH;Park KS;Jang HC;Lim S
脂肪堆积在机器人室可能会增加代谢风险。测量与代谢综合征（MS）相关的区域脂肪沉积的增量效用尚未得到很好的描述，特别是在老年人群中。作为韩国健康与老龄化纵向研究的一部分，这是一项以社区为基础的65岁以上人群的队列研究，研究对象（287名男性，75.9±8.6岁，278名女性，76.0±8.8岁）使用双能x线吸收仪测量android/gynoid区域，内脏/皮下脂肪组织（VAT/SAT）的计算机断层扫描，以及包括脂联素和高敏CRP在内的心脏代谢标志物，纳入了区域身体成分数据。我们在多元回归模型中研究了区域身体成分与MS之间的关系。男性VAT和SAT平均面积分别为131.4±65.5 cm2和126.9±55.2 cm2 (P = 0.045)，女性分别为120.0±46.7 cm2和211.8±65.9 cm2 （P<0.01）。男性平均脂肪量为1.8±0.8 kg、2.5±0.8 kg，女性平均脂肪量为2.0±0.6 kg、3.3±0.8 kg （P均<0.01）。与SAT或雌性脂肪相比，VAT面积和android脂肪量与大多数代谢危险因素密切相关。此外，在调整了年龄、性别、脂联素、hsCRP（胰岛素抵抗的替代标志物）、全身脂肪量和VAT面积等多个参数后，android脂肪量与MS成分的聚类有显著相关。我们的发现与假设的android脂肪在ms中作为致病脂肪库的作用是一致的。测量android脂肪可以更全面地了解与脂肪分布变化相关的代谢风险。
Fat accumulation in android compartments may confer increased metabolic risk. The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population. As part of the Korean Longitudinal Study on Health and Aging, which is a community-based cohort study of people aged more than 65 years, subjects (287 male, 75.9±8.6 years and 278 female, 76.0±8.8 years) with regional body composition data using Dual energy X-ray absorptiometry for android/gynoid area, computed tomography for visceral/subcutaneous adipose tissue (VAT/SAT), and cardiometabolic markers including adiponectin and high-sensitivity CRP were enrolled. We investigated the relationship between regional body composition and MS in multivariate regression models. Mean VAT and SAT area was 131.4±65.5 cm2 and 126.9±55.2 cm2 in men (P = 0.045) and 120.0±46.7 cm2 and 211.8±65.9 cm2 in women (P<0.01). Mean android and gynoid fat amount was 1.8±0.8 kg and 2.5±0.8 kg in men and 2.0±0.6 kg and 3.3±0.8 kg in women, respectively (both P<0.01). VAT area and android fat amount was strongly correlated with most metabolic risk factors compared to SAT or gynoid fat. Furthermore, android fat amount was significantly associated with clustering of MS components after adjustment for multiple parameters including age, gender, adiponectin, hsCRP, a surrogate marker of insulin resistance, whole body fat mass and VAT area. Our findings are consistent with the hypothesized role of android fat as a pathogenic fat depot in the MS. Measurement of android fat may provide a more complete understanding of metabolic risk associated with variations in fat distribution.
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影响因子：
16.2
作者：
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通讯作者：
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