The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes.
The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes.
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DOI：
10.1289/ehp.1307175
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发表时间：
2014-10
影响因子：
10.4
通讯作者：
Sutton P
中科院分区：
文献类型：
--
作者：
Woodruff TJ;Sutton P
背景：综合了解健康的环境驱动因素有助于采取以预防为导向的行动。环境卫生研究中常用的研究综合方法落后于近20年来临床科学中发展起来的系统综述方法。目标：我们试图开发“导航指南”的概念证明，这是一种系统和透明的环境健康研究综合方法。讨论：《导航指南》的方法建立在循证医学和环境卫生综合研究的最佳做法之上。与目前在环境卫生领域流行的以专家为基础的叙述性审查方法不同的关键点包括预先规定的协议、标准化和透明的文件（包括专家判断）、全面的搜索策略、“偏见风险”评估以及科学与价值观和偏好的分离。背离循证医学的关键点包括对人体观察性研究给予“中等”质量评级，并将各种证据流结合起来。结论：导航指南方法是一种系统和严格的研究综合方法，旨在减少环境卫生信息评估中的偏见并最大限度地提高透明度。虽然该方法的新方面还需要进一步的开发和验证，但我们的研究结果表明，国家毒理学计划正在开发和美国环境保护署正在考虑的改进的研究合成方法是完全可以实现的。将强有力的系统和透明的审查方法制度化将提供一个具体的机制，将科学与及时的行动联系起来，以防止伤害。引用本文：Woodruff TJ， Sutton P. 2014。《导航指南》系统审查方法：将环境卫生科学转化为更好的卫生成果的一种严格和透明的方法。环境卫生展望122:1007-1014；http://dx.doi.org/10.1289/ehp.1307175
Background: Synthesizing what is known about the environmental drivers of health is instrumental to taking prevention-oriented action. Methods of research synthesis commonly used in environmental health lag behind systematic review methods developed in the clinical sciences over the past 20 years. Objectives: We sought to develop a proof of concept of the “Navigation Guide,” a systematic and transparent method of research synthesis in environmental health. Discussion: The Navigation Guide methodology builds on best practices in research synthesis in evidence-based medicine and environmental health. Key points of departure from current methods of expert-based narrative review prevalent in environmental health include a prespecified protocol, standardized and transparent documentation including expert judgment, a comprehensive search strategy, assessment of “risk of bias,” and separation of the science from values and preferences. Key points of departure from evidence-based medicine include assigning a “moderate” quality rating to human observational studies and combining diverse evidence streams. Conclusions: The Navigation Guide methodology is a systematic and rigorous approach to research synthesis that has been developed to reduce bias and maximize transparency in the evaluation of environmental health information. Although novel aspects of the method will require further development and validation, our findings demonstrated that improved methods of research synthesis under development at the National Toxicology Program and under consideration by the U.S. Environmental Protection Agency are fully achievable. The institutionalization of robust methods of systematic and transparent review would provide a concrete mechanism for linking science to timely action to prevent harm. Citation: Woodruff TJ, Sutton P. 2014. The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environ Health Perspect 122:1007–1014; http://dx.doi.org/10.1289/ehp.1307175
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