Perfluorinated compounds in umbilical cord blood and adverse birth outcomes.
Perfluorinated compounds in umbilical cord blood and adverse birth outcomes.
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DOI：
10.1371/journal.pone.0042474
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Hsieh WS
中科院分区：
文献类型：
--
作者：
Chen MH;Ha EH;Wen TW;Su YN;Lien GW;Chen CY;Chen PC;Hsieh WS
以前的动物研究表明，全氟化合物（pfc）对出生结果有不利影响，但对人类的研究结果尚无定论。我们调查了产前暴露于全氟辛酸（PFOA）、全氟辛基磺酸（PFOS）、全氟壬酸（PFNA）和全氟癸酸（PFUA）与出生结局之间的关系。总共从台湾出生小组研究（TBPS）中招募了429对母婴。人口统计数据是通过使用结构化问卷采访母亲获得的，出生结果是从医疗记录中提取的。采集脐带血，采用超高效液相色谱/串联质谱法对PFOA、PFOS、PFNA和PFUA进行分析。脐带血PFOA、PFOS、PFNA和PFUA的几何平均值（标准差）分别为1.84（2.23）、5.94（1.95）、2.36（4.74）和10.26 (3.07)ng/mL。只有PFOS水平与胎龄、出生体重和头围呈负相关[每ln单位：调整后的β(95%可信区间，CI) = - 0.37（- 0.60, - 0.13）周，- 110.2 (- 176.0,- 44.5)gm和- 0.25 (- 0.46,- 0.05)cm]。此外，早产、低出生体重和小胎龄的优势比随着全氟辛烷磺酸暴露而增加[每ln单位：校正优势比（OR） (95%CI) = 2.45（1.47, 4.08）、2.61（0.85,8.03）和2.27(1.25,4.15)]。当全氟辛烷磺酸水平被分成四分位数时，观察到剂量-反应关系。然而，PFOA、PFNA和PFUA并没有被观察到对出生结果有任何令人信服的影响。在产前全氟辛烷磺酸暴露和出生结局之间观察到不良剂量依赖性关联。然而，其他检查的pfc没有发现关联。
Previous animal studies have shown that perfluorinated compounds (PFCs) have adverse impacts on birth outcomes, but the results have been inconclusive in humans. We investigated associations between prenatal exposure to perfluorooctanoic acid (PFOA), perfluorooctyl sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) and birth outcomes. In total, 429 mother-infant pairs were recruited from the Taiwan Birth Panel Study (TBPS). Demographic data were obtained by interviewing mothers using a structured questionnaire and birth outcomes were extracted from medical records. Cord blood was collected for PFOA, PFOS, PFNA, and PFUA analysis by ultra-high-performance liquid chromatography/tandem mass spectrometry. The geometric mean (standard deviation) levels of PFOA, PFOS, PFNA, and PFUA in cord blood plasma were 1.84 (2.23), 5.94 (1.95), 2.36(4.74), and 10.26 (3.07) ng/mL, respectively. Only PFOS levels were found to be inversely associated with gestational age, birth weight, and head circumference [per ln unit: adjusted β (95% confidence interval, CI) = −0.37 (−0.60, −0.13) wks, −110.2 (−176.0, −44.5) gm and −0.25 (−0.46, −0.05) cm]. Additionally, the odds ratio of preterm birth, low birth weight, and small for gestational age increased with PFOS exposure [per ln unit: adjusted odds ratio (OR) (95%CI) = 2.45 (1.47, 4.08), 2.61(0.85, 8.03) and 2.27 (1.25, 4.15)]. When PFOS levels were divided into quartiles, a dose-response relation was observed. However, PFOA, PFNA, and PFUA were not observed to have any convincing impact on birth outcomes. An adverse dose-dependent association was observed between prenatal PFOS exposure and birth outcomes. However, no associations were found for the other examined PFCs.
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影响因子：
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作者：
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