Embryonic differentiation of serotonin‐containing neurons in the enteric nervous system of the locust (Locusta migratoria)
Embryonic differentiation of serotonin‐containing neurons in the enteric nervous system of the locust (Locusta migratoria)
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蝗虫肠神经系统中含血清素神经元的胚胎分化（Locusta migratoria）
DOI：
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Gerd Bicker
中科院分区：
文献类型：
--
作者：
M. Stern;S. Knipp;Gerd Bicker
蝗虫的肠道神经系统由位于前肠的四个神经节(额神经节、下脑神经节和成对的粘液神经节)以及支配前肠和中肠的神经丛组成。5-羟色胺是ENS的主要神经递质之一，已知在肠道运动和进食中起着至关重要的作用。在整个胚胎发育过程中，我们对5-羟色胺能系统进行了解剖。5-羟色胺能神经元产生于前肠的前神经源区，并沿发育中的返神经向吻侧迁移，从而参与额神经节的形成。它们长出下行神经突起，分布在所有肠神经节和两个神经丛中。在中肠上，神经突起紧随主要的迁移的中肠神经元。5-羟色胺的合成大约发生在发育的中途--中肠闭合开始的时候。发育成5-羟色胺能表型的细胞表达5-羟色胺摄取转运体(SERT)的时间明显更早，从发育的40%开始。神经元在沿返神经迁移的过程中开始表达SERT，这表明它们在到达最终目的地之前致力于5-羟色胺能表型。在完成肠神经节的布局后(60%)，随后是成熟期，在此期间，5-羟色胺免疫反应阳性细胞体增大，神经丛中的细枝形成静脉曲张，推测是5-羟色胺释放的部位(80%)。这项研究为进一步研究5-羟色胺在ENS发育过程中潜在的形态调节功能提供了初步的步骤。J.Comp.神经。501：38-51,2007.©2007 Wiley-Liss Inc.
The enteric nervous system (ENS) of the locust consists of four ganglia (frontal and hypocerebral ganglion, and the paired ingluvial ganglia) located on the foregut, and nerve plexus innervating fore‐ and midgut. One of the major neurotransmitters of the ENS, serotonin, is known to play a vital role in gut motility and feeding. We followed the anatomy of the serotonergic system throughout embryonic development. Serotonergic neurons are generated in the anterior neurogenic zones of the foregut and migrate rostrally along the developing recurrent nerve to contribute to the frontal ganglion. They grow descending neurites, which arborize in all enteric ganglia and both nerve plexus. On the midgut, the neurites closely follow the leading migrating midgut neurons. The onset of serotonin synthesis occurs around halfway through development—the time of the beginning of midgut closure. Cells developing to serotonergic phenotype express the serotonin uptake transporter (SERT) significantly earlier, beginning at 40% of development. The neurons begin SERT expression during migration along the recurrent nerve, indicating that they are committed to a serotonergic phenotype before reaching their final destination. After completion of the layout of the enteric ganglia (at 60%) a maturational phase follows, during which serotonin‐immunoreactive cell bodies increase in size and the fine arborizations in the nerve plexus develop varicosities, putative sites of serotonin release (at 80%). This study provides the initial step for future investigation of potential morphoregulatory functions of serotonin during ENS development. J. Comp. Neurol. 501:38–51, 2007. © 2007 Wiley‐Liss, Inc.
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影响因子：
4.6
作者：
Martha J. Lundell;Jay Hirsh
通讯作者：
Martha J. Lundell;Jay Hirsh
成束蛋白 II 的不同亚型在昆虫胚胎发生过程中指导神经元迁移中发挥不同的作用。
DOI：
10.1006/dbio.2000.9777
发表时间：
2000
期刊：
Developmental biology.
影响因子：
--
作者：
Wright,JW;Copenhaver,PF
通讯作者：
Copenhaver,PF
影响因子：
2.7
作者：
J. Wright;K. M. Schwinof;M. Snyder;P. F. Copenhaver
通讯作者：
J. Wright;K. M. Schwinof;M. Snyder;P. F. Copenhaver
龙虾（Homarus americanus）发育中的口胃系统中的血清素。
DOI：
10.1002/neu.10136
发表时间：
2003
期刊：
Journal of neurobiology
影响因子：
--
作者：
Richards,KathrynS;Simon,DavidJ;Pulver,StefanR;Beltz,BarbaraS;Marder,Eve
通讯作者：
Marder,Eve