Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case--control study.
Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case--control study.
复制标题
DOI：
10.1038/bjc.1996.330
复制
发表时间：
1996-07
影响因子：
8.8
通讯作者：
Quipourt, V
中科院分区：
文献类型：
--
作者：
Boutron, MC;Faivre, J;Marteau, P;Couillault, C;Senesse, P;Quipourt, V
在盎格鲁撒克逊人中已经描述了钙对结直肠癌的保护作用，但在拉丁社区中却没有描述，并且在腺瘤中没有观察到这种作用。我们通过比较小腺瘤（< 10 mm，n = 154）、大腺瘤（n = 208）和无息肉（n = 426）受试者以及癌症病例（n = 171）与人群对照（n = 309），研究了法国地区钙、乳制品和腺瘤-癌序列之间的关系。除低脂钙和男性大腺瘤外，钙对结直肠肿瘤没有保护作用（最高五分位数的 OR = 0.3，趋势 P = 0.06）。男性摄入乳制品钙和女性摄入非乳制品钙甚至有增加癌症风险的趋势。维生素 D 与女性患小腺瘤的风险呈负相关（最高五分位数的 OR = 0.4，趋势 P = 0.04）。对于乳制品，只有酸奶的摄入量与男性和女性患大腺瘤的风险呈负相关。这些数据未能证明钙对结直肠癌的保护作用。他们认为乳制品的类型可能是预防结直肠肿瘤的重要因素。
A protective effect of calcium against colorectal cancer has been described in Anglo-Saxon but not in Latin communities, and no such effect has been observed regarding adenomas. We investigated the relationship between calcium, dairy products and the adenoma-carcinoma sequence in a French region by comparing small adenoma ( < 10 mm, n = 154), large adenoma (n = 208) and polyp-free (n = 426) subjects, and cancer cases (n = 171) with population controls (n = 309). There was no protective effect of calcium against colorectal tumours except for low fat calcium and large adenomas in men (OR for highest quintile = 0.3, P for trend = 0.06). There was even a trend towards an increased risk of cancer with dairy calcium in men and non-dairy calcium in women. Vitamin D was inversely related to the risk of small adenomas in women (OR for highest quintile = 0.4, P for trend = 0.04). Regarding dairy products, only consumption of yoghurt displayed an inverse relationship with risk of large adenomas, in both men and women. These data failed to demonstrate a protective effect of calcium against colorectal carcinogenesis. They suggest that the type of dairy product might be the important factor with regard to prevention of colorectal tumours.
登录
查看更多内容
影响因子：
1.9
作者：
RAFTER, JJ
通讯作者：
RAFTER, JJ
影响因子：
8.8
作者：
Wu AH;Paganini-Hill A;Ross RK;Henderson BE
通讯作者：
Henderson BE
影响因子：
2.9
作者：
BOUTRON, MC;FAIVRE, J;ESTEVE, J
通讯作者：
ESTEVE, J
影响因子：
5
作者：
KAMPMAN, E;GIOVANNUCCI, E;WILLETT, WC
通讯作者：
WILLETT, WC
DOI：
10.1097/00008469-199403000-00007
发表时间：
1994-03-01
期刊：
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
影响因子：
--
作者：
Piard, F;Martin, M;Martin, F
通讯作者：
Martin, F