Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability.
Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability.
复制标题
DOI：
10.1007/s10571-014-0074-5
复制
发表时间：
2014-10
影响因子：
4
通讯作者：
Perry, George
中科院分区：
文献类型：
--
作者：
Rodrigues, Roberto;Petersen, Robert B.;Perry, George
关键词：
氧化应激是导致抑郁症和阿尔茨海默病的重要因素。涉及的主要因素是炎性细胞因子、下丘脑垂体轴、下丘脑垂体性腺和精氨酸加压素系统，当由心理社会应激、严重危及生命的事件以及精神情感和躯体疾病触发时，这些系统诱导糖皮质激素和“氧化物能”级联反应。在具有抑郁症基因脆弱性的个体中，这些级联可能导致慢性抑郁-焦虑-压力谱，导致MDD和其他已知的抑郁综合征。相比之下，在阿尔茨海默病基因组易感性受试者中，氧化应激诱导的脑损伤触发特异性抗氧化防御，即淀粉样蛋白-β（Aβ）水平升高和过度磷酸化tau聚集，导致成对螺旋丝和ApoEε4亚型相关功能受损，导致复杂的病理级联反应，最终导致AD。令人惊讶的是，在这篇综述中提到的所有AD相关的分子途径已被证明是相似或类似的抑郁症中发现的那些，包括结构损伤，即海马和额叶皮质萎缩。还提到了其他相互作用的分子信号，即GSK-3β、会聚性存活因子（脑源性神经营养因子和热休克蛋白）和过渡氧化还原金属，以强调在MDD和AD中可通过类似机制相互作用的大量中间体。
The thesis of this review is that oxidative stress is the central factor in major depressive disorder (MDD) and Alzheimer’s disease (AD). The major elements involved are inflammatory cytokines, the hypothalamic pituitary axis, the hypothalamic pituitary gonadal, and arginine vasopressin systems, which induce glucocorticoid and “oxidopamatergic” cascades when triggered by psychosocial stress, severe life threatening events, and mental-affective and somatic diseases. In individuals with a genomic vulnerability to depression these cascades may result in chronic depression-anxiety-stress spectra, resulting in MDD and other known depressive syndromes. In contrast, in subjects with genomic vulnerability to Alzheimer’s disease, oxidative stress-induced brain damage triggers specific antioxidant defenses, i.e. increased levels of amyloid-β (Aβ) and aggregation of hyper-phosphorylated tau, resulting in paired helical filaments and impaired functions related to the ApoEε4 isoform, leading to complex pathological cascades culminating in AD. Surprisingly, all the AD associated molecular pathways mentioned in this review have been shown to be similar or analogous to those found in depression, including structural damage, i.e. hippocampal and frontal cortex atrophy. Other interacting molecular signals, i.e. GSK-3β, convergent survival factors (brain-derived neurotrophic factor and heat shock proteins), and transition-redox metals are also mentioned to emphasize the vast array of intermediates that could interact via comparable mechanisms in both MDD and AD.
登录
查看更多内容
DOI：
10.1073/pnas.1834314100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Avshalumov, MV;Rice, ME
通讯作者：
Rice, ME
DOI：
10.1073/pnas.1012851108
发表时间：
2010-12-28
影响因子：
11.1
作者：
Caccamo, Antonella;Maldonado, Monica A.;Oddo, Salvatore
通讯作者：
Oddo, Salvatore
影响因子：
17.7
作者：
Ballmaier, Martina;Narr, Katherine L.;Kumar, Anand
通讯作者：
Kumar, Anand
影响因子：
10.6
作者：
Berman, RM;Cappiello, A;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
6.6
作者：
Bilici, M;Efe, H;Deger, O
通讯作者：
Deger, O