The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.
The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.
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DOI：
10.1007/s10552-013-0150-z
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发表时间：
2013-04
影响因子：
2.3
通讯作者：
Thornquist, Mark D.
中科院分区：
文献类型：
--
作者：
Patterson, Ruth E.;Colditz, Graham A.;Hu, Frank B.;Schmitz, Kathryn H.;Ahima, Rexford S.;Brownson, Ross C.;Carson, Kenneth R.;Chavarro, Jorge E.;Chodosh, Lewis A.;Gehlert, Sarah;Gill, Jeff;Glanz, Karen;Haire-Joshu, Debra;Herbst, Karen Louise;Hoehner, Christine M.;Hovmand, Peter S.;Irwin, Melinda L.;Jacobs, Linda A.;James, Aimee S.;Jones, Lee W.;Kerr, Jacqueline;Kibel, Adam S.;King, Irena B.;Ligibel, Jennifer A.;Meyerhardt, Jeffrey A.;Natarajan, Loki;Neuhouser, Marian L.;Olefsky, Jerrold M.;Proctor, Enola K.;Redline, Susan;Rock, Cheryl L.;Rosner, Bernard;Sarwer, David B.;Schwartz, J. Sanford;Sears, Dorothy D.;Sesso, Howard D.;Stampfer, Meir J.;Subramanian, S. V.;Taveras, Elsie M.;Tchou, Julia;Thompson, Beti;Troxel, Andrea B.;Wessling-Resnick, Marianne;Wolin, Kathleen Y.;Thornquist, Mark D.
认识到过度肥胖和癌症控制结果之间复杂，多方面的关系，促使科学界寻求新的研究模型和范式。美国国家癌症研究所提出了一个创新的概念，建立了一个中心的资助机制，在营养，能量学和身体活动;被称为能量学和癌症的跨学科研究（TREC）倡议。本文概述了2011-2016年TREC合作网络和在中心进行的15个研究项目。2011年，四所学术机构获得了TREC中心的赠款：哈佛大学、加州圣地亚哥大学、宾夕法尼亚大学和圣路易斯的华盛顿大学。弗雷德哈钦森癌症研究中心是协调中心。TREC研究组合包括3项动物研究、3项队列研究、4项随机临床试验、1项横断面研究和2项建模研究。TREC研究人员所代表的学科包括基础科学、内分泌学、流行病学、生物统计学、行为学、医学、营养学、体育活动、遗传学、工程学、卫生经济学和计算机科学。大约41，000名参与者将参与这些研究，包括儿童，健康成人以及乳腺癌和前列腺癌幸存者。结果包括癌症风险的生物标志物、体重和体力活动的变化、持续的不良治疗作用（例如，水肿、泌尿和性功能）以及乳腺癌和前列腺癌死亡率。团队科学小组的NIH科学将评估这种合作科学的附加值。然而，最重要的结果将是这种跨学科的举措是否改善了美国癌症风险以及癌症幸存者的健康。
Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms. The National Cancer Institute developed an innovative concept to establish a centers grant mechanism in nutrition, energetics, and physical activity; referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the Centers. Four academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes 3 animal studies, 3 cohort studies, 4 randomized clinical trials, 1 cross-sectional study, and 2 modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality. The NIH Science of Team Science group will evaluate the value-added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk for cancer as well as cancer survivors.
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DOI：
10.1249/mss.0b013e3182059eda
发表时间：
2011-06-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Arikawa, Andrea Y.;Thomas, William;Kurzer, Mindy S.
通讯作者：
Kurzer, Mindy S.
影响因子：
9.7
作者：
Finkelstein, Eric A.;Trogdon, Justin G.;Dietz, William
通讯作者：
Dietz, William
影响因子：
4.7
作者：
Basen-Engquist, Karen;Chang, Maria
通讯作者：
Chang, Maria
影响因子：
158.5
作者：
Schmitz, Kathryn H.;Ahmed, Rehana L.;Greene, Quincy P.
通讯作者：
Greene, Quincy P.
影响因子：
8.4
作者：
Friedenreich, Christine M.;Neilson, Heather K.;Lynch, Brigid M.
通讯作者：
Lynch, Brigid M.