Utility of (18)F FDG-PET/CT for predicting prognosis of luminal-type breast cancer.
Utility of (18)F FDG-PET/CT for predicting prognosis of luminal-type breast cancer.
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DOI：
10.1007/s10549-015-3303-9
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发表时间：
2015-02
影响因子：
3.8
通讯作者：
Okada, Morihito
中科院分区：
文献类型：
--
作者：
Aogi, Kenjiro;Kadoya, Takayuki;Sugawara, Yoshifumi;Kiyoto, Sachiko;Shigematsu, Hideo;Masumoto, Norio;Okada, Morihito
激素受体阳性乳腺癌的术后预后优于其他表型；然而，对于复发或生存没有明确的预测因素。本研究旨在评估18f -氟-2-脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）的最大标准化摄取值（SUVmax）和临床病理特征作为激素受体阳性乳腺癌患者术后无复发生存期（RFS）和总生存期（OS）的可能预测因素。我们评估了2006年1月至2011年12月在两家机构术前接受FDG-PET/CT检查的262例I-III期乳腺癌诊断为腔型（腔型A， 166例；腔型B， 96例）。评估SUVmax与临床病理因素（年龄、临床T/N分期、核分级、淋巴结转移及血管侵犯）的关系。为了纠正两个机构在PET/CT分析上的差异，我们进行了一项幻像研究。根据OS的SUVmax cutoff on receiver operating characteristic （ROC）分析进行分组（≤6.0组vs. >6.0组，AUC = 0.742）。临床t因子、核分级与SUVmax有显著相关性（p < 0.0001、p = 0.0092）。在使用Cox模型进行复发的单因素和多因素分析中，SUVmax在各特征中具有显著性（分别为p = 0.013和p = 0.055）。RFS曲线显示，SUVmax≤6.0组预后明显好于SUVmax≤6.0组（p = 0.004）。同样，SUVmax对OS有显著性意义（p = 0.007和p = 0.008）。SUVmax≤6.0和>6.0组的OS差异有统计学意义（p < 0.001）。SUVmax可用于预测光型乳腺癌患者的预后。
Postoperative prognosis is better for hormonal receptor-positive breast cancer than for other phenotypes; however, there are no definitive predictive factors for relapse or survival. This study aimed to evaluate the maximum standardized uptake value (SUVmax) on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) and clinicopathological characteristics as possible predictors of postoperative relapse-free survival (RFS) and overall survival (OS) in hormonal receptor-positive breast cancer patients. We evaluated 262 patients with Stage I–III breast cancer diagnosed as luminal type (luminal A, 166; luminal B, 96 patients) who underwent preoperative FDG-PET/CT between January 2006 and December 2011 at two institutions. The relationships among SUVmax and clinicopathological factors (age, clinical T/N stage, nuclear grade, lymph node metastasis and vascular invasion) were evaluated. A phantom study was performed to correct differences in PET/CT analysis between two institutions. The patients were divided according to the SUVmax cutoff on receiver operating characteristic (ROC) analysis for OS (≤6.0 group vs. >6.0 group, AUC = 0.742). Clinical T-factor and nuclear grade were significantly correlated with SUVmax (p < 0.0001 and p = 0.0092, respectively). In the uni- and multivariate analyses using the Cox model for relapse, SUVmax was significant (p = 0.013 and p = 0.055, respectively) among characteristics. RFS curves showed that prognosis was significantly better for the SUVmax ≤ 6.0 group than for the SUVmax > 6.0 group (p = 0.004). Similarly, SUVmax was significant for OS (p = 0.007 and p = 0.008). OS was significantly different between the SUVmax ≤ 6.0 and >6.0 groups (p < 0.001). SUVmax was useful for predicting outcomes in patients with luminal-type breast cancer.
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DOI：
10.1007/s002590050319
发表时间：
1998-10-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Crippa, F;Seregni, E;Bombardieri, E
通讯作者：
Bombardieri, E
DOI：
10.1093/jnci/djs451
发表时间：
2012-12-19
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Groheux D;Hindié E;Delord M;Giacchetti S;Hamy AS;de Bazelaire C;de Roquancourt A;Vercellino L;Toubert ME;Merlet P;Espié M
通讯作者：
Espié M
DOI：
10.1093/jnci/djt244
发表时间：
2013-10-02
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Sestak I;Dowsett M;Zabaglo L;Lopez-Knowles E;Ferree S;Cowens JW;Cuzick J
通讯作者：
Cuzick J
影响因子：
6.2
作者：
Basu, Sandip;Chen, Wengen;Alavi, Abass
通讯作者：
Alavi, Abass
影响因子：
20.4
作者：
Berghmans, Thierry;Dusart, Michele;Sculier, Jean-Paul
通讯作者：
Sculier, Jean-Paul