Pregnancy Alters Renal and Blood Burden of Mercury in Females.

Pregnancy Alters Renal and Blood Burden of Mercury in Females.
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DOI:
10.1007/s12011-018-1278-1
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发表时间:
2018-11
影响因子:
3.9
通讯作者:
Bridges CC
Bridges CC
中科院分区:
生物学3区
文献类型:
--
作者:
Orr SE;Franklin RC;George HS;Nijhara S;Joshee L;Bridges CC

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甲基汞(CH3Hg+)是一种常见的环境毒物,对许多器官系统都有严重的有害影响。我们假设,一个重大的生理变化,如怀孕,可以改变汞的处置和积累。为了验证这一假设,怀孕和未怀孕的雌性Wistar大鼠口服暴露于CH3Hg+。妊娠大鼠血液中汞含量和总肾块明显低于未妊娠大鼠。这一发现可能是由于怀孕大鼠的血浆容量扩大和汞的稀释,导致母体血液和肾脏中的汞水平降低。
Methylmercury (CH3Hg+), a common environmental toxicant, has serious detrimental effects in numerous organ systems. We hypothesize that a significant physiological change, like pregnancy, can alter the disposition and accumulation of mercury. To test this hypothesis, pregnant and non-pregnant female Wistar rats were exposed orally to CH3Hg+. The amount of mercury in blood and total renal mass was significantly lower in pregnant rats than in non-pregnant rats. This finding may be due to expansion of plasma volume in pregnant rats and dilution of mercury, leading to lower levels of mercury in maternal blood and kidneys.
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