An observational study of malaria in British travellers: Plasmodium ovale wallikeri and Plasmodium ovale curtisi differ significantly in the duration of latency.
An observational study of malaria in British travellers: Plasmodium ovale wallikeri and Plasmodium ovale curtisi differ significantly in the duration of latency.
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DOI：
10.1136/bmjopen-2013-002711
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发表时间：
2013-05-28
期刊：
影响因子：
2.9
通讯作者：
Sutherland CJ
中科院分区：
文献类型：
--
作者：
Nolder D;Oguike MC;Maxwell-Scott H;Niyazi HA;Smith V;Chiodini PL;Sutherland CJ
卵形疟疾是由两种密切相关的原生动物寄生虫引起的：卵形疟原虫（Plasmodium ovale curtisi）和卵形疟原虫（Plasmodium ovale wallikeri）虽然在遗传上有明显的不同，但没有研究比较这些寄生虫的形态，生命周期或流行病学。我们测试的假设，这两个物种不同的潜伏期之前，呈现血液阶段感染的症状。PCR用于鉴定来自英国疟疾患者的存档血液中的P ovale curtisi和P ovale wallikeri感染。潜伏期，估计进入英国和诊断疟疾之间的时间，比较两组之间。英国国家参考实验室。没有。存档的寄生虫材料和监测数据74 P卵圆形curtisi和60 P卵圆形wallikeri感染进行了分析。其他流行病学数据来自1045例输入性病例的数据库。没有。通过详细比较存档血片中的寄生虫形态（分别为N=9，N=8）和性别比（N=5，N=4），未发现两种物种之间存在差异。瓦氏卵圆线虫的几何平均潜伏期为40.6天（95% CI 28.9至57.0），而短椭圆线虫的几何平均潜伏期为85.7天（95% CI 66.1至111.1; p=0.002）的两倍多。 此外，在报告使用化学预防药物的患者中，卵形广义疟疾的比例高于恶性疟原虫（OR 7.56; p<0.0001）或间日疟原虫（OR 1.82; p<0.0001）。这些研究结果提供了两种寄生虫引起卵形疟疾之间观察到的流行病学意义的第一个差异，并表明针对恶性疟原虫的控制措施可能不足以减少卵形疟原虫和卵形疟原虫引起的疟疾负担。
Ovale malaria is caused by two closely related species of protozoan parasite: Plasmodium ovale curtisi and Plasmodium ovale wallikeri Although clearly distinct genetically, there have been no studies comparing the morphology, life cycle or epidemiology of these parasites. We tested the hypothesis that the two species differ in the duration of latency prior to presentation with symptoms of blood-stage infection. PCR was used to identify P ovale curtisi and P ovale wallikeri infections among archived blood from UK malaria patients. Latency periods, estimated as the time between entry into the UK and diagnosis of malaria, were compared between the two groups. UK National Reference Laboratory. None. Archived parasite material and surveillance data for 74 P ovale curtisi and 60 P ovale wallikeri infections were analysed. Additional epidemiological data were taken from a database of 1045 imported cases. None. No differences between the two species were identified by a detailed comparison of parasite morphology (N=9, N=8, respectively) and sex ratio (N=5, N=4) in archived blood films. The geometric mean latency period in P ovale wallikeri was 40.6 days (95% CI 28.9 to 57.0), whereas that for P ovale curtisi was more than twice as long at 85.7 days (95% CI 66.1 to 111.1; p=0.002). Further, the proportion of ovale malaria sensu lato which occurred in patients reporting chemoprophylaxis use was higher than for Plasmodium falciparum (OR 7.56; p<0.0001) or P vivax (OR 1.82; p<0.0001). These findings provide the first difference of epidemiological significance observed between the two parasites which cause ovale malaria, and suggest that control measures aimed at P falciparum may not be adequate for reducing the burden of malaria caused by P ovale curtisi and P ovale wallikeri.
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