Occupational exposure and new-onset asthma in a population-based study in Northern Europe (RHINE).
Occupational exposure and new-onset asthma in a population-based study in Northern Europe (RHINE).
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DOI：
10.1093/annhyg/mes083
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Torén K
中科院分区：
文献类型：
--
作者：
Lillienberg L;Andersson E;Janson C;Dahlman-Höglund A;Forsberg B;Holm M;Glslason T;Jögi R;Omenaas E;Schlünssen V;Sigsgaard T;Svanes C;Torén K
在一项以北欧成年人为对象的大规模人群研究中，研究了职业性暴露与新发哮喘之间的关系。这项研究包括13284名出生于1945年至1973年之间的受试者，他们分别回答了1989-1992年和1999-2001年的问卷调查。哮喘被定义为“由医生诊断的哮喘”，报告的诊断年份。使用改进的工作暴露矩阵和COX回归模型中的高危职业计算1980-2000年间新发成人哮喘的危险比(HR)。这些分析分别针对男性和女性进行，并对过敏症进行了分层。在观察期内，有429例新发哮喘患者，男性每千人年哮喘发病率为1.3例，女性为2.4例。暴露于植物相关抗原(HR=3.6；95%CI=1.4-9.0)、环氧树脂(HR=2.4；95%CI=1.3-4.5)、二异氰酸酯(HR=2.1；95%CI=1.2-3.7)和意外峰值刺激物暴露(HR=2.4；95%CI=1.3-4.7)的男性新发哮喘显著增加。接触清洁剂的男性和女性都有更高的哮喘风险。当对特应性进行分层时，暴露于丙烯酸酯(HR=3.3；95%CI=1.4-7.5)、环氧化合物(HR=3.6；95%CI=1.6-7.9)、二异氰酸酯和意外峰值刺激物暴露(HR=3.0；95%CI=1.2-7.2)的非特应性男性哮喘风险增加。职业性哮喘的人群归因风险男性为14%，女性为7%。这项以人群为基础的研究表明，接触环氧树脂、二异氰酸酯和丙烯酸酯的男性新发哮喘的风险增加。非特应性皮肤病的风险似乎比特应性皮肤病的风险更高，除了暴露于高分子量剂之外。清洁工、喷漆工、水管工和理发师的哮喘风险增加已得到证实。
In a large population-based study among adults in northern Europe the relation between occupational exposure and new-onset asthma was studied. The study comprised 13 284 subjects born between 1945 and 1973, who answered a questionnaire 1989–1992 and again 1999–2001. Asthma was defined as ‘Asthma diagnosed by a physician’ with reported year of diagnose. Hazard ratios (HR), for new-onset adult asthma during 1980–2000, were calculated using a modified job-exposure matrix as well as high-risk occupations in Cox regression models. The analyses were made separately for men and women and were also stratified for atopy. During the observation period there were 429 subjects with new-onset asthma with an asthma incidence of 1.3 cases per 1000 person-years for men and 2.4 for women. A significant increase in new-onset asthma was seen for men exposed to plant-associated antigens (HR = 3.6; 95% CI [confidence interval] = 1.4–9.0), epoxy (HR = 2.4; 95% CI = 1.3–4.5), diisocyanates (HR = 2.1; 95% CI = 1.2–3.7) and accidental peak exposures to irritants (HR = 2.4; 95% CI = 1.3–4.7). Both men and women exposed to cleaning agents had an increased asthma risk. When stratifying for atopy an increased asthma risk were seen in non-atopic men exposed to acrylates (HR = 3.3; 95% CI = 1.4–7.5), epoxy compounds (HR = 3.6; 95% CI = 1.6–7.9), diisocyanates and accidental peak exposures to irritants (HR = 3.0; 95% CI = 1.2–7.2). Population attributable risk for occupational asthma was 14% for men and 7% for women. This population-based study showed that men exposed to epoxy, diisocyanates and acrylates had an increased risk of new-onset asthma. Non-atopics seemed to be at higher risk than atopics, except for exposure to high molecular weight agents. Increased asthma risks among cleaners, spray painters, plumbers, and hairdressers were confirmed.
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DOI：
10.1164/ajrccm.164.4.2012146
发表时间：
2001-08-15
影响因子：
24.7
作者：
Karjalainen, A;Kurppa, K;Karjalainen, J
通讯作者：
Karjalainen, J
影响因子：
4.3
作者：
Toren, Kjell;Ekerljung, Linda;Lundback, Bo
通讯作者：
Lundback, Bo
影响因子：
168.9
作者：
Kogevinas, Manolis;Zock, Jan-Paul;Anto, Josep M.
通讯作者：
Anto, Josep M.
影响因子：
3.1
作者：
Toren, Kjell;Blanc, Paul D
通讯作者：
Blanc, Paul D
影响因子：
168.9
作者：
Kogevinas, M;Antó, JM;Burney, P
通讯作者：
Burney, P