Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study
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含硼生物活性玻璃对聚己内酯成骨和血管生成的刺激作用：体外研究
DOI：
10.1155/2019/8961409
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发表时间：
2019-03
影响因子：
--
通讯作者：
Yuanjin Xu
中科院分区：
文献类型：
--
作者：
Lunguo Xia;Wudi Ma;Yuning Zhou;Zhipeng Gui;Akimichi Takemura;Mamoru Uemura;Kailin Lin;Yuanjin Xu
聚己内酯（PCL）因其成本低、韧性高、加工性能好等优点而成为骨再生材料的研究热点。然而，纯PCL的相对较低的弹性模量、疏水性和生物活性不足限制了其在骨再生中的广泛应用。在本研究中，研究了含硼生物活性玻璃（B-BG）材料的加入对PCL聚合物的机械性能和生物性能的影响，其中B-BG含量为0、10、20、30和40 wt.%，以评价B-BG/PCL复合材料在骨再生中的潜在应用。结果表明，与纯PCL聚合物相比，B-BG/PCL复合材料具有更好的拉伸强度、人体中性pH值和更快的降解速度。此外，与纯PCL聚合物相比，B-BG的掺入可以增强大鼠骨髓基质细胞（rBMSCs）的增殖、成骨分化和血管生成因子表达。重要的是，B-BG还促进人脐静脉内皮细胞（HUVECs）的血管生成分化。这些增强效应具有B-BG含量的浓度依赖性，而30重量% B-BG/PCL复合材料的刺激效果最好。因此，30 wt.% B-BG/PCL复合材料在骨重建领域具有潜在的应用前景。
Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone regeneration. In the present study, the effects of the addition of boron containing bioactive glass (B-BG) materials on the mechanical properties and biological performance of PCL polymer were investigated with different B-BG contents (0, 10, 20, 30, and 40 wt.%), in order to evaluate the potential applications of B-BG/PCL composites for bone regeneration. The results showed that the B-BG/PCL composites possess better tensile strength, human neutral pH value, and fast degradation as compared to pure PCL polymers. Moreover, the incorporation of B-BG could enhance proliferation, osteogenic differentiation, and angiogenic factor expression for rat bone marrow stromal cells (rBMSCs) as compared to pure PCL polymers. Importantly, the B-BG also promoted the angiogenic differentiation for human umbilical vein endothelial cells (HUVECs). These enhanced effects had a concentration dependence of B-BG content, while 30 wt.% B-BG/PCL composites achieved the greatest stimulatory effect. Therefore the 30 wt.% B-BG/PCL composites have potential applications in bone reconstruction fields.
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DOI：
10.1016/j.ijbiomac.2018.04.045
发表时间：
2018-08-01
影响因子：
8.2
作者：
Sharifi, Fereshteh;Atyabi, Seyed Mohammad;Bakhshi, Hadi
通讯作者：
Bakhshi, Hadi
DOI：
10.1016/j.msec.2009.05.013
发表时间：
2009-08-31
影响因子：
7.9
作者：
Fu, Hailuo;Fu, Qiang;Liu, Xin
通讯作者：
Liu, Xin
塑料的生物降解性。
影响因子：
5.6
作者：
Tokiwa Y;Calabia BP;Ugwu CU;Aiba S
通讯作者：
Aiba S
影响因子：
--
作者：
Romagnoli C;Zonefrati R;Galli G;Puppi D;Pirosa A;Chiellini F;Martelli FS;Tanini A;Brandi ML
通讯作者：
Brandi ML
影响因子：
14
作者：
Kim, HW;Knowles, JC;Kim, HE
通讯作者：
Kim, HE