Long-term impact of chronic variable stress in adolescence versus adulthood.
Long-term impact of chronic variable stress in adolescence versus adulthood.
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DOI：
10.1016/j.pnpbp.2018.08.003
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发表时间：
2019-01-10
影响因子：
5.6
通讯作者：
Paglini MG
中科院分区：
文献类型：
--
作者：
Cotella EM;Gómez AS;Lemen P;Chen C;Fernández G;Hansen C;Herman JP;Paglini MG
青春期是应激调节神经回路活跃发展的时期。因此，控制对压力的反应的机制在这一发育时期没有完全成熟，这可能导致对慢性压力的脆弱性。我们假设青少年的慢性压力会对以后的生活中的压力适应产生负面影响。雄性Wistar大鼠（PND 40）进行2周的慢性可变应激（CVS），每天随机提供2个应激源，每周两次过夜的社会应激源。五周后，使用高架十字迷宫（ESTA）和强迫游泳试验（FST）对成年期的动物进行评估。下丘脑-垂体-肾上腺（HPA）轴对30分钟约束的反应也进行了评估。将结果与CVS停止后5周测试的成年大鼠的结果进行比较。我们的研究结果表明，CVS的长期影响是特定的应用程序的压力制度的年龄。我们展示了行为和HPA轴反应以及下丘脑室旁核激活如何随年龄而不同，导致青春期应激动物的不同行为适应和成年期应激动物HPA轴的失调，这些数据强调了青春期在确定HPA轴弹性和编程行为反应方面的重要性。
Adolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result in vulnerability to chronic stress. We hypothesized that adolescent chronic stress would have negative consequences on stress adaptation later in life. Male Wistar rats (PND40) were subjected to chronic variable stress (CVS) for 2 weeks, with 2 daily stressors randomly presented and overnight social stressors twice a week. After five weeks, animals were evaluated during adulthood, using the elevated plus maze (EPM) and the forced swim test (FST). The hypothalamic-pituitary adrenal (HPA) axis response to a 30-min restraint was also assessed. Results are compared to those of adult rats tested 5 weeks following CVS cessation. Our results demonstrate that the long-term effects of CVS are specific to the age of application of the stress regime. We show how behavior and HPA axis response as well as hypothalamic paraventricular nucleus activation can differ with age, resulting in differential behavioral adaptations for animals stressed in adolescence and dysregulation of the HPA axis in the animals stressed in adulthood, These data underscore the importance of the adolescent period in determining resilience of the HPA axis and programming behavioral responses later in life.
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DOI：
10.1002/cne.22359
发表时间：
2010-07-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Cressman VL;Balaban J;Steinfeld S;Shemyakin A;Graham P;Parisot N;Moore H
通讯作者：
Moore H
影响因子：
3.7
作者：
Eiland, Lisa;Ramroop, Johnny;Hill, Matthew N.;Manley, Jasmine;McEwen, Bruce S.
通讯作者：
McEwen, Bruce S.
影响因子：
4.1
作者：
HERMAN, JP;ADAMS, D;PREWITT, C
通讯作者：
PREWITT, C
影响因子：
3.5
作者：
Isgor, C;Kabbaj, M;Watson, SJ
通讯作者：
Watson, SJ
影响因子：
17.7
作者：
Lewinsohn, PM;Rohde, P;Gotlib, LH
通讯作者：
Gotlib, LH