Biosensing technologies for Mycobacterium tuberculosis detection: status and new developments.

Biosensing technologies for Mycobacterium tuberculosis detection: status and new developments.
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DOI:
10.1155/2011/193963
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发表时间:
2011
影响因子:
--
通讯作者:
Qin D
Qin D
中科院分区:
其他
文献类型:
--
作者:
Zhou L;He X;He D;Wang K;Qin D

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生物传感技术有望改善临床诊断、食品分析、生物过程和环境监测中结核分枝杆菌(M. tuberculosis)的检测和管理。基于不同的生物元件识别系统和基本信号传感器原理,已经开发出多种便携式、快速、灵敏的生物传感器,可立即“现场”解释,用于结核分枝杆菌检测。在这里,我们概述了结核分枝杆菌检测生物传感技术的最新发展,这些技术根据基本信号传感器原理进行分类,包括压电石英晶体生物传感器、电化学生物传感器和磁致弹性生物传感器。特别关注改进生物传感器的框架和分析参数的方法,包括灵敏度和分析时间以及分析程序的自动化。本文的最后部分还讨论了结核分枝杆菌检测生物传感技术发展的挑战和前景。
Biosensing technologies promise to improve Mycobacterium tuberculosis (M. tuberculosis) detection and management in clinical diagnosis, food analysis, bioprocess, and environmental monitoring. A variety of portable, rapid, and sensitive biosensors with immediate “on-the-spot” interpretation have been developed for M. tuberculosis detection based on different biological elements recognition systems and basic signal transducer principles. Here, we present a synopsis of current developments of biosensing technologies for M. tuberculosis detection, which are classified on the basis of basic signal transducer principles, including piezoelectric quartz crystal biosensors, electrochemical biosensors, and magnetoelastic biosensors. Special attention is paid to the methods for improving the framework and analytical parameters of the biosensors, including sensitivity and analysis time as well as automation of analysis procedures. Challenges and perspectives of biosensing technologies development for M. tuberculosis detection are also discussed in the final part of this paper.
DOI: 10.2116/analsci.18.397
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