A small-scale field trial of pyriproxyfen-impregnated bed nets against pyrethroid-resistant Anopheles gambiae s.s. in western Kenya.
A small-scale field trial of pyriproxyfen-impregnated bed nets against pyrethroid-resistant Anopheles gambiae s.s. in western Kenya.
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DOI：
10.1371/journal.pone.0111195
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Minakawa N
中科院分区：
文献类型：
--
作者：
Kawada H;Dida GO;Ohashi K;Kawashima E;Sonye G;Njenga SM;Mwandawiro C;Minakawa N
对拟除虫菊酯的抗药性正在成为病媒控制方案的一个主要问题，因为目前，拟除虫菊酯的合适化学替代品很少，因为当用于蚊帐时，杀虫剂必须具有低哺乳动物毒性以及对蚊子的高活性。吡丙醚（PPF）是保幼激素模拟物（JHM）中活性最高的化学物质之一。用PPF杀灭蚊虫可能是一种潜在的控制抗药性疟疾病媒的措施。研究了1%PPF浸渍蚊帐和1%PPF +2%氯菊酯浸渍蚊帐（Olyset Duo）对抗拟除虫菊酯冈比亚按蚊（Anopheles gambiae s.s.）在肯尼亚西部。在使用PPF浸渍蚊帐的房屋中，在采集后3天观察到吸血蚊子的高死亡率，表明PPF对接触蚊帐的蚊子寿命的影响。在使用Olyset Duo和PPS浸渍蚊帐的房屋中，也观察到产卵雌性数量、卵数量和每只雌性后代数量减少。这是第一次现场研究表明PPF对野生拟除虫菊酯抗性An具有高杀菌效果。冈比亚有限公司人口此外，我们认识到氯菊酯与PPF联合使用的必要性，以减少蚊虫叮咬的风险并提供一定程度的个人保护。对拟除虫菊酯类杀虫剂抗性的野生蚊种群如按蚊的进一步研究。arabiensis和安.富内斯图斯公司将提供更多关于PPF浸渍蚊帐实际使用的信息。
Pyrethroid resistance is becoming a major problem for vector control programs, because at present, there are few suitable chemical substitutes for pyrethroids, as when used on bed nets the insecticide must have low mammalian toxicity as well as high activity to mosquitoes. Pyriproxyfen (PPF) is one of the most active chemicals among the juvenile hormone mimic (JHM) group. Sterilizing mosquitoes by using PPF could be a potential control measure for pyrethroid-resistant malaria vectors. We investigated the sterilizing effects of two types of PPF-impregnated bed nets – a 1% PPF-impregnated net and a 1% PPF +2% permethrin-impregnated net (Olyset Duo) – to pyrethroid-resistant wild population of Anopheles gambiae s.s. in western Kenya. High mortality of blood-fed mosquitos was observed 3 days post-collection, in the houses where PPF-impregnated nets were used, indicating the effect of PPF on the longevity of mosquitos that came in contact with the net. Reduction in the number of ovipositing females, number of eggs, and number of progeny per female were also observed in the houses in which both Olyset Duo and PPF-impregnated nets were used. This is the first field study showing the high sterilizing efficacy of PPF against wild pyrethroid-resistant An. gambiae s.s. population. In addition, we recognized the necessity of combined use of permethrin with PPF, in order to reduce the risk of mosquito bites and provide a level of personal protection. Further studies on wild pyrethroid-resistant mosquito populations such as An. arabiensis and An. funestus s.s. would provide more information on the practical use of the PPF-impregnated bed nets.
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影响因子：
2.1
作者：
Ebrahimi B;Shakibi S;Foster WA
通讯作者：
Foster WA
影响因子：
3.2
作者：
Harris C;Lwetoijera DW;Dongus S;Matowo NS;Lorenz LM;Devine GJ;Majambere S
通讯作者：
Majambere S
影响因子：
2.1
作者：
Meola, R;Pullen, S;Meola, S
通讯作者：
Meola, S
影响因子：
2.1
作者：
Dasgupta, Ranjit;Free, Heather M.;Christensen, Bruce M.
通讯作者：
Christensen, Bruce M.
影响因子：
3.2
作者：
Futami K;Dida GO;Sonye GO;Lutiali PA;Mwania MS;Wagalla S;Lumumba J;Kongere JO;Njenga SM;Minakawa N
通讯作者：
Minakawa N