Comparative analysis of the macroscale structural connectivity in the macaque and human brain.
Comparative analysis of the macroscale structural connectivity in the macaque and human brain.
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DOI：
10.1371/journal.pcbi.1003529
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发表时间：
2014-03
影响因子：
4.3
通讯作者：
Stiers P
中科院分区：
文献类型：
--
作者：
Goulas A;Bastiani M;Bezgin G;Uylings HB;Roebroeck A;Stiers P
猕猴大脑是人类大脑的模型，但它的适用性受到了人类独特功能的挑战，包括灵长类进化过程中出现的连接重新配置。我们对这两个物种的全脑宏观结构连通性进行了定量的比较分析。我们的发现表明，人类和猕猴的大脑作为一个整体是相似的。区域分析揭示了物种间连接模式的许多相似之处，但也缺乏这些相似之处，主要涉及扣带区域。我们揭示了这两个物种的共同结构骨架，涉及一组高度重叠的区域。这种结构主干对于整个大脑的信息传递很重要，似乎构成了灵长类大脑持久化进化的一个特征。我们的发现说明了宏观尺度连通性水平上的新的进化方面，并在猕猴和人类研究之间提供了一座定量的转换桥梁。与其他灵长类动物的大脑相比，人类大脑有什么共同之处和不同之处？大脑可以被设想为一个复杂的网络。它的拓扑性质制约着它的功能。由于伦理和技术原因，有必要使用猕猴等动物大脑作为人脑的模型。然而，进化上的变化，包括“大脑重新连接”，可能会导致独特的人类特征。因此，需要对这两个物种的大脑连接进行详细和定量的比较分析。在这里，我们通过采用与其他科学领域比较研究中使用的技术类似的技术来承担这项任务。我们的方法揭示了汇聚但也发散的布线模式。作为一个整体，这两个物种的大脑有着相似的联系。大多数大脑区域似乎具有进化保守的连接模式，而对于某些区域，情况似乎并非如此。我们还在这两个物种的大脑中发现了一个进化上保守的“结构脊梁”。我们的发现突出了这两个灵长类物种大脑共同而独特的“连接特性”，并为将研究结果从猕猴研究转化为人类研究提供了量化基础。
The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research. What are the commonalities and differences of human brains when compared to the brains of other primates? The brain can be conceived as a complex network. Its topological properties constrain its function. Ethical and technical reasons necessitate the use of animal brains, like the macaque monkey, as models for the human brain. However, evolutionary changes, including “brain rewiring”, might result in unique human features. Hence, a detailed and quantitative comparative analysis of the connectivity of the brains of the two species is needed. Here, we undertake this task by adopting techniques analogous to those used in comparative studies in other scientific fields. Our approach reveals converging but also diverging wiring patterns. The brain of the two species as a whole is similarly wired. The majority of the brain regions appear to have evolutionary conserved connectivity patterns while for certain regions this appears not to be the case. We also uncover an evolutionary conserved “structural backbone” in the brain of the two species. Our findings highlight common and unique “wiring properties” of the brains of these two primate species and offer a quantitative basis for translating findings from macaque research to human research.
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影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
5.3
作者：
Croxson, PL;Johansen-Berg, H;Rushworth, MFS
通讯作者：
Rushworth, MFS
影响因子：
7.8
作者：
Bezgin, Gleb;Wanke, Egon;Koetter, Rolf
通讯作者：
Koetter, Rolf
影响因子：
16.2
作者：
de Pasquale F;Della Penna S;Snyder AZ;Marzetti L;Pizzella V;Romani GL;Corbetta M
通讯作者：
Corbetta M
影响因子：
5.7
作者：
Fillard, Pierre;Descoteaux, Maxime;Poupon, Cyril
通讯作者：
Poupon, Cyril