Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study.
Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study.
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DOI：
10.1007/s10552-011-9885-6
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发表时间：
2012-02
影响因子：
2.3
通讯作者：
Robsahm, Trude Eid
中科院分区：
文献类型：
--
作者：
Tretli, Steinar;Schwartz, Gary G.;Torjesen, Peter Abusdal;Robsahm, Trude Eid
我们研究了挪威癌症患者血清25-羟基维生素D （25-OHD）水平与死亡风险之间的关系。研究人群为658例乳腺癌（n = 251）、结肠癌（n = 52）、肺癌（n = 210）和淋巴瘤（n = 145）患者，来自挪威以人群为基础的血清库JANUS。在癌症诊断90天内收集血清样本并分析25-OHD。患者在1984年至2004年期间被诊断出来，并在2008年期间随访死亡。我们使用Cox回归模型评估血清25-OHD与死亡风险之间的关系。399例患者在随访期间死亡，其中343例（86%）死于癌症。经性别、诊断时年龄和采血季节调整后，诊断时25-OHD水平低于46 nmol/L的患者生存期较短。与血清25-OHD最低四分位数的患者相比，最高四分位数的患者癌症死亡风险显著降低（HR 0.36, 95% CI 0.27, 0.51）。癌症死亡风险的估计变化在第一和第二四分位数之间最为明显。在所有四种癌症中都观察到25-OHD水平与生存之间的关联。较高的循环血清25-OHD水平与乳腺癌、结肠癌、肺癌和淋巴瘤的生存率呈正相关。
We investigated the association between serum levels of 25-hydroxyvitamin D (25-OHD) and risk of death in Norwegian cancer patients. The study population was 658 patients with cancers of the breast (n = 251), colon (n = 52), lung (n = 210), and lymphoma (n = 145), obtained from JANUS, a population-based serum bank in Norway. Serum samples were collected within 90 days of cancer diagnosis and were analyzed for 25-OHD. Patients were diagnosed during 1984–2004 and were followed for death throughout 2008. We used Cox regression models to assess the relationship between serum 25-OHD and risk of death. Three hundred and ninety-nine patients died during follow-up, of whom 343 (86%) died from cancer. Adjusted for sex, age at diagnosis, and season of blood sampling, patients with 25-OHD levels below 46 nmol/L at diagnosis experienced shorter survival. Compared to patients in the lowest quartile of serum 25-OHD, the risk of cancer death among patients in the highest quartile was significantly reduced (HR 0.36 95% CI 0.27, 0.51). The estimated change in risk of cancer death was most pronounced between the first and the second quartile. The associations between 25-OHD levels and survival were observed for all four cancers. Higher circulating serum levels of 25-OHD were positively associated with the survival for cancers of the breast, colon, lung, and lymphoma.
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影响因子：
5.3
作者：
Porojnicu, Alina Carmen;Robsahm, Trude Eid;Moan, Johan
通讯作者：
Moan, Johan
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad
影响因子：
8.4
作者：
Larsen, Inger Kristin;Smastuen, Milada;Moller, Bjorn
通讯作者：
Moller, Bjorn
影响因子：
2.3
作者：
Holick, Michael F.
通讯作者：
Holick, Michael F.
DOI：
10.1016/j.jsbmb.2004.03.068
发表时间：
2004-05-01
影响因子：
4.1
作者：
Trump, DL;Hershberger, PA;Johnson, CS
通讯作者：
Johnson, CS