An efficient Pt@MXene platform for the analysis of small-molecule natural products.
An efficient Pt@MXene platform for the analysis of small-molecule natural products.
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用于小分子天然产物分析的高效Pt@MXene平台。
DOI：
10.1016/j.isci.2023.106622
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发表时间：
2023-05-19
期刊：
影响因子：
5.8
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhang G;Ma C;He Q;Dong H;Cui L;Li L;Li L;Wang Y;Wang X
Small-molecule (m/z<500) natural products have rich biological activity and significant application value thus need to be effectively detected. Surface-assisted laser desorption/ionization mass spectrometry (SALDI MS) has become a powerful detection tool for small-molecule analysis. However, more efficient substrates need to be developed to improve the efficiency of SALDI MS. Thus, platinum nanoparticle-decorated Ti3C2 MXene (Pt@MXene) was synthesized in this study as an ideal substrate for SALDI MS in positive ion mode and exhibited excellent performance for the high-throughput detection of small molecules. Compared with using MXene, GO, and CHCA matrix, a stronger signal peak intensity and wider molecular coverage was obtained using Pt@MXene in the detection of small-molecule natural products, with a lower background, excellent salt and protein tolerance, good repeatability, and high detection sensitivity. The Pt@MXene substrate was also successfully used to quantify target molecules in medicinal plants. The proposed method has potentially wide application. An ideal Pt@MXene nanosubstrate was synthesized for SALDI MS analysis Pt@MXene platform is suitable for the analysis of various small-molecule natural products Pt@MXene platform enables high-throughput detection in complex biosamples Pt@MXene platform can accurately quantify small-molecule natural products Materials property; Biomaterials; Nanomaterials
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