COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight.
COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight.
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DOI：
10.1177/10760296221107889
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发表时间：
2022-01
影响因子：
2.9
通讯作者：
Zahran, Asmaa M.
中科院分区：
文献类型：
--
作者：
El-Badawy, Omnia;Elsherbiny, Nahla M.;Abdeltawab, Doaa;Magdy, Doaa M.;Bakkar, Lamees M.;Hassan, Shimaa A.;Hassan, Elham A.;Thabet, Ahmed M.;Ashmawy, Ahmed M.;Moustafa, Ehab F.;Abbas, Wael A.;Ahmad, Ahmad Bahieldeen;Rayan, Amal;Saad, Khaled;Elhoufey, Amira;Hussein, Hosni A. M.;Thabet, Ali A.;Zahran, Asmaa M.
我们研究的目的是研究临床和实验室特征，这些特征可作为预测疾病严重程度、IL-10水平和共病COVID-19患者不同T细胞亚群频率的生物标志物。对62名患有合并症的住院COVID-19患者进行了临床和放射学评估。采用流式细胞术检测外周血T淋巴细胞亚群，ELISA法检测外周血IL-10水平。在COVID-19患者中观察到的最常见合并症是糖尿病（DM）、高血压和恶性肿瘤。常见症状和体征包括发热、咳嗽、呼吸困难、疲劳、肌痛和咽喉痛。CRP、铁蛋白、D二聚体、LDH、尿素、肌酐和直接胆红素在患者中显著高于对照组。在共病COVID-19患者中，淋巴细胞计数和CD 4+和CD 8 + T细胞显著降低，CD 25和CD 45 RA表达增加。CD 4+和CD 8+调节性T细胞（TcR）和IL-10水平在患者中显著降低。在我们的研究中，发现许多参数可以预测共病患者的严重程度。CD 4+和CD 8 + T细胞的水平和活化显著降低，此外，患者中的CD 4+和CD 8 + T细胞显著降低，可能指出CD 8 + T细胞在抑制CD 4 + T细胞活化中的突出作用。
Our study's objectives were to study the clinical and laboratory characteristics that may serve as biomarkers for predicting disease severity, IL-10 levels, and frequencies of different T cell subsets in comorbid COVID-19 patients. Sixty-two hospitalized COVID-19 patients with comorbidities were assessed clinically and radiologically. Blood samples were collected to assess the T lymphocyte subsets by flow cytometry and IL-10 levels by ELISA. The most common comorbidities observed in COVID-19 patients were diabetes mellitus (DM), hypertension, and malignancies. Common symptoms and signs included fever, cough, dyspnea, fatigue, myalgia, and sore throat. CRP, ferritin, D dimer, LDH, urea, creatinine, and direct bilirubin were significantly increased in patients than controls. Lymphocyte count and CD4+ and CD8+ T-cells were significantly decreased in comorbid COVID-19 patients, and CD25 and CD45RA expression were increased. CD4+ and CD8+ regulatory T cells (Tregs) and IL-10 levels were significantly decreased in patients. Many parameters were found to be predictive of severity in the comorbid patients in our study. Significant reductions in the levels and activation of CD4+ and CD8+ T-cells were found. In addition, CD4+ and CD8+ Tregs were significant decreased in patients, probably pointing to a prominent role of CD8+ Tregs in dampening CD4+ T-cell activation.
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影响因子：
4.1
作者：
Rojas JM;Avia M;Martín V;Sevilla N
通讯作者：
Sevilla N
影响因子：
6.4
作者：
Libri, Valentina;Azevedo, Rita I.;Akbar, Arne N.
通讯作者：
Akbar, Arne N.
影响因子：
5.2
作者：
Han, Yi;Zhang, Haidong;Gu, Guorong
通讯作者：
Gu, Guorong
影响因子：
11.8
作者：
Qin, Chuan;Zhou, Luoqi;Tian, Dai-Shi
通讯作者：
Tian, Dai-Shi
影响因子：
100.3
作者：
Chen, Zeyu;John Wherry, E.
通讯作者：
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