Phase-change nanoparticles using highly volatile perfluorocarbons: toward a platform for extravascular ultrasound imaging.
Phase-change nanoparticles using highly volatile perfluorocarbons: toward a platform for extravascular ultrasound imaging.
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DOI：
10.7150/thno.4846
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发表时间：
2012
期刊：
影响因子：
12.4
通讯作者：
Dayton PA
中科院分区：
文献类型：
--
作者：
Matsunaga TO;Sheeran PS;Luois S;Streeter JE;Mullin LB;Banerjee B;Dayton PA
最近使用全氟化碳 (PFC) 纳米粒子与声学液滴汽化相结合的努力，使得将超声造影剂的诊断和治疗能力扩展到血管空间之外成为可能。我们的实验室利用高挥发性 PFC 十氟丁烷（DFB，bp =-2 °C）和八氟丙烷（OFP，bp =-37 °C）开发了相变纳米颗粒 (PCN)，用于声学液滴汽化。使用常用临床超声扫描仪进行的研究表明，PCN 乳液的蒸发频率和机械指数可显着降低组织生物效应。此外，这些造影剂可以配制为在生理温度下稳定，并且可以混合全氟化碳以调节超声敏感性和总体稳定性之间的平衡。我们在此讨论我们最近为开发用于组织询问的微调诊断/分子成像剂所做的努力。我们讨论了目前正在调查的研究以及可能因用低沸点 PFC 配制 PCN 而出现的潜在诊断和治疗范例。
Recent efforts using perfluorocarbon (PFC) nanoparticles in conjunction with acoustic droplet vaporization has introduced the possibility of expanding the diagnostic and therapeutic capability of ultrasound contrast agents to beyond the vascular space. Our laboratories have developed phase-change nanoparticles (PCNs) from the highly volatile PFCs decafluorobutane (DFB, bp =-2 °C) and octafluoropropane (OFP, bp =-37 °C ) for acoustic droplet vaporization. Studies with commonly used clinical ultrasound scanners have demonstrated the ability to vaporize PCN emulsions with frequencies and mechanical indices that may significantly decrease tissue bioeffects. In addition, these contrast agents can be formulated to be stable at physiological temperatures and the perfluorocarbons can be mixed to modulate the balance between sensitivity to ultrasound and general stability. We herein discuss our recent efforts to develop finely-tuned diagnostic/molecular imaging agents for tissue interrogation. We discuss studies currently under investigation as well as potential diagnostic and therapeutic paradigms that may emerge as a result of formulating PCNs with low boiling point PFCs.
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