Astrocyte Clocks and Glucose Homeostasis.
Astrocyte Clocks and Glucose Homeostasis.
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DOI：
10.3389/fendo.2021.662017
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发表时间：
2021
影响因子：
5.2
通讯作者：
López M
中科院分区：
文献类型：
--
作者：
Barca-Mayo O;López M
内源性计时系统进化为通过地球自转 24 小时周期来预测一天中的时间。在哺乳动物中，生物钟控制着有节奏的生理和行为过程，包括葡萄糖代谢、食物摄入、能量消耗和全身胰岛素敏感性的日常波动。一系列研究的结果表明，人类和啮齿动物昼夜节律周期的环境或遗传改变与肥胖和2型糖尿病等代谢疾病密切相关。新的证据表明，星形胶质细胞时钟在调节分子、生理和行为昼夜节律（如葡萄糖代谢和胰岛素敏感性）方面发挥着至关重要的作用。鉴于 2 型糖尿病和昼夜节律紊乱的并发高患病率，了解生物钟及其失调调节血糖稳态的机制可能会改善血糖控制。在这篇综述中，我们总结了目前关于计时系统、葡萄糖稳态和胰岛素敏感性之间紧密联系的知识。我们特别关注星形胶质细胞时钟在有机体、细胞和分子水平上参与葡萄糖代谢的调节。
The endogenous timekeeping system evolved to anticipate the time of the day through the 24 hours cycle of the Earth’s rotation. In mammals, the circadian clock governs rhythmic physiological and behavioral processes, including the daily oscillation in glucose metabolism, food intake, energy expenditure, and whole-body insulin sensitivity. The results from a series of studies have demonstrated that environmental or genetic alterations of the circadian cycle in humans and rodents are strongly associated with metabolic diseases such as obesity and type 2 diabetes. Emerging evidence suggests that astrocyte clocks have a crucial role in regulating molecular, physiological, and behavioral circadian rhythms such as glucose metabolism and insulin sensitivity. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying glucose homeostasis regulation by the circadian clock and its dysregulation may improve glycemic control. In this review, we summarize the current knowledge on the tight interconnection between the timekeeping system, glucose homeostasis, and insulin sensitivity. We focus specifically on the involvement of astrocyte clocks, at the organism, cellular, and molecular levels, in the regulation of glucose metabolism.
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影响因子：
7.7
作者：
Barker A;Sharp SJ;Timpson NJ;Bouatia-Naji N;Warrington NM;Kanoni S;Beilin LJ;Brage S;Deloukas P;Evans DM;Grontved A;Hassanali N;Lawlor DA;Lecoeur C;Loos RJ;Lye SJ;McCarthy MI;Mori TA;Ndiaye NC;Newnham JP;Ntalla I;Pennell CE;St Pourcain B;Prokopenko I;Ring SM;Sattar N;Visvikis-Siest S;Dedoussis GV;Palmer LJ;Froguel P;Smith GD;Ekelund U;Wareham NJ;Langenberg C
通讯作者：
Langenberg C
影响因子：
16.6
作者：
Barca-Mayo O;Pons-Espinal M;Follert P;Armirotti A;Berdondini L;De Pietri Tonelli D
通讯作者：
De Pietri Tonelli D
影响因子：
3.6
作者：
Bosy-Westphal, Anja;Hinrichs, Silvia;Mueller, Manfred James
通讯作者：
Mueller, Manfred James
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
5.3
作者：
Bushong, EA;Martone, ME;Ellisman, MH
通讯作者：
Ellisman, MH