Epidemiology of Japanese encephalitis in the Philippines: a systematic review.
Epidemiology of Japanese encephalitis in the Philippines: a systematic review.
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DOI：
10.1371/journal.pntd.0003630
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发表时间：
2015-03
影响因子：
3.8
通讯作者：
Fox KK
中科院分区：
文献类型：
--
作者：
Lopez AL;Aldaba JG;Roque VG Jr;Tandoc AO 3rd;Sy AK;Espino FE;DeQuiroz-Castro M;Jee Y;Ducusin MJ;Fox KK
日本脑炎病毒（JEV）是亚洲大部分地区脑炎的重要原因，病死率高，幸存者中往往有严重的神经系统后遗症。日本脑炎在菲律宾的流行病学还没有很好的定义。为了支持考虑将乙脑疫苗引入菲律宾的国家计划，我们进行了系统的文献综述，并总结了2011年至2014年的乙脑监测数据。我们在四个数据库和一个图书馆进行了日本脑炎和菲律宾的搜索。对2011年1月至2014年3月期间急性脑炎综合征和乙脑监测以及国家参考实验室的数据进行了制表和绘图。我们确定了29份已发表的关于菲律宾乙脑的报告和介绍，包括5份血清学调查，18份临床病例报告和8项动物研究（包括两项临床病例和动物数据）。18项临床研究报告了1972年至2013年期间257例实验室确诊的乙脑病例。乙脑病毒（JEV）在临床脑膜炎和脑炎合并病例中占7%~ 18%，在临床脑炎病例中占16%~ 40%。乙脑主要影响15岁以下的儿童，6%至7%的病例导致死亡。2011年1月至2014年3月的监测数据在检测的497例病例中确定了73例（15%）实验室确诊的乙脑病例。这一全面的审查表明了日本脑炎在菲律宾的地方性和广泛的地理范围，并支持在该国使用日本脑炎疫苗。需要通过实验室确认继续和改进监测，以系统地量化乙脑负担，提供信息，指导国家高风险地区的优先次序，确定适当的接种年龄和时间表，并衡量预防措施的影响，包括针对这一重要的公共卫生威胁的免疫接种。日本脑炎病毒（JEV）是亚洲神经系统感染的重要原因，导致大量残疾和死亡。虽然被认为是菲律宾的地方病，但对该国这种疾病的流行病学和地理分布知之甚少。我们回顾了自20世纪50年代以来的临床研究、患病率调查和动物研究数据。根据这项审查，JEV是该国所有三个主要岛屿群脑炎和发热疾病的重要原因。大多数病例见于15岁以下的儿童，男性比女性更常受到影响。国家实验室于2009年开始对转诊病例进行检测，并于2011年对急性脑炎综合征进行监测，并对部分病例进行实验室确认。从2011年到2014年，有1，032例疑似乙脑病例。在497例样本检测病例中，73例（15%）经实验室确认为乙脑。我们的研究结果证实，日本脑炎在菲律宾有广泛的地理分布。这些发现支持将乙脑疫苗引入该国的常规免疫规划。
Japanese encephalitis virus (JEV) is an important cause of encephalitis in most of Asia, with high case fatality rates and often significant neurologic sequelae among survivors. The epidemiology of JE in the Philippines is not well defined. To support consideration of JE vaccine for introduction into the national schedule in the Philippines, we conducted a systematic literature review and summarized JE surveillance data from 2011 to 2014. We conducted searches on Japanese encephalitis and the Philippines in four databases and one library. Data from acute encephalitis syndrome (AES) and JE surveillance and from the national reference laboratory from January 2011 to March 2014 were tabulated and mapped. We identified 29 published reports and presentations on JE in the Philippines, including 5 serologic surveys, 18 reports of clinical cases, and 8 animal studies (including two with both clinical cases and animal data). The 18 clinical studies reported 257 cases of laboratory-confirmed JE from 1972 to 2013. JE virus (JEV) was the causative agent in 7% to 18% of cases of clinical meningitis and encephalitis combined, and 16% to 40% of clinical encephalitis cases. JE predominantly affected children under 15 years of age and 6% to 7% of cases resulted in death. Surveillance data from January 2011 to March 2014 identified 73 (15%) laboratory-confirmed JE cases out of 497 cases tested. This comprehensive review demonstrates the endemicity and extensive geographic range of JE in the Philippines, and supports the use of JE vaccine in the country. Continued and improved surveillance with laboratory confirmation is needed to systematically quantify the burden of JE, to provide information that can guide prioritization of high risk areas in the country and determination of appropriate age and schedule of vaccine introduction, and to measure the impact of preventive measures including immunization against this important public health threat. Japanese encephalitis virus (JEV) is an important cause of neurologic infections in Asia, resulting in substantial disability and deaths. Although believed to be endemic in the Philippines, little is known of the epidemiology and geographic distribution of this disease in the country. We reviewed data from clinical studies, prevalence surveys and animal studies since the 1950s. Based on this review, JEV is an important cause of encephalitis and febrile illness in all three major island groups of the country. The majority of cases were seen in children younger than 15 years and males were more often affected than females. The national laboratory initiated testing of referred cases in 2009 and surveillance for acute encephalitis syndrome (AES) with laboratory confirmation of a subset of cases was established in 2011. From 2011 to 2014, there were 1,032 cases of suspected JE. Of 497 cases with specimens tested, 73 (15%) had laboratory-confirmed JE. Our findings confirm that JE has an extensive geographic distribution in the Philippines. These findings support the introduction of JE vaccine into the country’s routine immunization program.
DOI：
10.4269/ajtmh.2010.09-0676
发表时间：
2010-05-01
影响因子：
3.3
作者：
Hills, Susan L.;Griggs, Anne C.;Fischer, Marc
通讯作者：
Fischer, Marc
DOI：
10.4269/ajtmh.1958.7.323
发表时间：
1958-01-01
影响因子：
3.3
作者：
HAMMON, WM;SCHRACK, WD;SATHER, GE
通讯作者：
SATHER, GE
影响因子：
0.7
作者：
Inoue, S;Morita, K;Natividad, FF
通讯作者：
Natividad, FF