High-frequency oscillations and other electrophysiological biomarkers of epilepsy: clinical studies.

High-frequency oscillations and other electrophysiological biomarkers of epilepsy: clinical studies.
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DOI:
10.2217/bmm.11.74
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发表时间:
2011-10
影响因子:
2.2
通讯作者:
Gotman J
Gotman J
中科院分区:
医学4区
文献类型:
--
作者:
Worrell G;Gotman J

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准确定位致痫灶是癫痫手术成功的关键。最近的研究表明,使用宽带宽的颅内脑电图发作间期的高频振荡优先定位于大脑区域产生自发性癫痫发作,是一个潜在的生物标志物的癫痫脑。癫痫发作间期,致痫性脑的电生理生物标志物的存在有可能通过改善定位和潜在地消除对慢性颅内EEG监测的依赖来改善结局,从而显著推进癫痫手术。
Accurate localization of epileptogenic brain is critical for successful epilepsy surgery. Recent research using wide bandwidth intracranial EEG has demonstrated that interictal high-frequency oscillations are preferentially localized to the brain region generating spontaneous seizures, and are a potential biomarker of epileptogenic brain. The existence of an interictal, electrophysiological biomarker of epileptogenic brain has the potential to significantly advance epilepsy surgery by improving outcomes through improved localization and potentially eliminating the reliance on chronic intracranial EEG monitoring.
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