The impact of different forms of exercise on endothelial progenitor cells in healthy populations.
The impact of different forms of exercise on endothelial progenitor cells in healthy populations.
复制标题
不同形式的运动对健康人群内皮祖细胞的影响。
DOI：
10.1007/s00421-022-04921-7
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发表时间：
2022-07
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
循环内皮祖细胞（EPCs）有助于血管愈合和新生血管，而运动是动员EPCs进入循环的有效手段。目的：系统地研究不同形式的运动对健康人群循环EPCs的急性和慢性影响。方法：遵循系统评价和荟萃分析指南的首选报告项目。结果：31篇文章符合纳入标准，受试者747人，年龄19 ~ 76岁。所有纳入的试验均使用流式细胞术鉴定循环EPCs。在急性和慢性试验中分别鉴定出8种和5种不同的EPC表型。在急性试验中，采用了中等强度连续训练（MICON）、最大强度、长时间耐力、阻力和高强度间歇训练（HIIT）运动方案。长时间耐力和阻力运动对循环EPCs的影响最为深远，其次是极限运动。在慢性试验中，确定了MICON锻炼、HIIT、HIIT与MICON的比较以及MICON与exergame（基于互动视频游戏的锻炼方式）的比较。MICON运动对久坐不动的老年人的循环EPCs有积极影响，并伴有内皮功能和动脉硬度的改善。在动员循环EPCs方面，长时间HIIT（每次4分钟）似乎是一种有效的手段，优于MICON运动。总之，在急性和慢性试验中，运动引起的EPC动员程度取决于所采用的运动方案。未来，需要更多的研究来检验不同运动形式对循环EPCs的剂量-反应关系，使用标准化方法和EPC表型。在线版本包含补充材料，可在10.1007/s00421-022-04921-7获得。
Circulating endothelial progenitor cells (EPCs) contribute to vascular healing and neovascularisation, while exercise is an effective means to mobilise EPCs into the circulation. Objectives: to systematically examine the acute and chronic effects of different forms of exercise on circulating EPCs in healthy populations. Methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed. Results: thirty-one articles met the inclusion criteria including 747 participants aged 19 to 76 years. All included trials used flow cytometry for identification of circulating EPCs. Eight and five different EPC phenotypes were identified in the acute and chronic trials, respectively. In the acute trials, moderate intensity continuous (MICON), maximal, prolonged endurance, resistance and high intensity interval training (HIIT) exercise protocols were utilised. Prolonged endurance and resistance exercise had the most profound effect on circulating EPCs followed by maximal exercise. In the chronic trials, MICON exercise, HIIT, HIIT compared to MICON and MICON compared to exergame (exercise modality based on an interactive video game) were identified. MICON exercise had a positive effect on circulating EPCs in older sedentary individuals which was accompanied by improvements in endothelial function and arterial stiffness. Long-stage HIIT (4 min bouts) appears to be an effective means and superior than MICON exercise in mobilising circulating EPCs. In conclusion, both in acute and chronic trials the degree of exercise-induced EPC mobilisation depends upon the exercise regime applied. In future, more research is warranted to examine the dose–response relationship of different exercise forms on circulating EPCs using standardised methodology and EPC phenotype. The online version contains supplementary material available at 10.1007/s00421-022-04921-7.
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影响因子：
3.3
作者：
Bonsignore, Maria R.;Morici, Giuseppe;Testa, Ugo
通讯作者：
Testa, Ugo
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
82.9
作者：
Aicher, A;Heeschen, C;Dimmeler, S
通讯作者：
Dimmeler, S
DOI：
10.1123/ijsnem.20.1.44
发表时间：
2010-02-01
影响因子：
2.5
作者：
Capostagno, Benoit;Bosch, Andrew
通讯作者：
Bosch, Andrew
DOI：
10.1111/j.1365-2362.2012.02670.x
发表时间：
2012-09-01
影响因子：
5.5
作者：
Cesari, Francesca;Sofi, Francesco;Casini, Alessandro
通讯作者：
Casini, Alessandro