3D imaging of tissue integration with porous biomaterials.
3D imaging of tissue integration with porous biomaterials.
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DOI：
10.1016/j.biomaterials.2008.06.018
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发表时间：
2008-10
期刊：
影响因子：
14
通讯作者：
Levenston, Marc E.
中科院分区：
文献类型：
--
作者：
Guldberg, Robert E.;Duvall, Craig L.;Peister, Alexandra;Oest, Megan E.;Lin, Angela S. P.;Palmer, Ashley W.;Levenston, Marc E.
设计用于支持细胞渗透和组织形成的多孔生物材料在种植体固定和组织工程化修复中发挥着关键作用。这篇引导性意见论文的目的是倡导使用高分辨率3D成像技术作为一种工具来量化多孔生物材料中细胞外基质的形成和血管内长，并客观地比较不同的功能组织再生策略。最初对定性评估方法的过度依赖可能导致了一种错误的看法，即开发有效的组织工程技术将相对简单。此外，在挑战临床前模型方面，缺乏与量化指标的比较研究，这使得很难确定许多可用策略中的哪一种分别投资于公司和临床医生或用于临床。本文将具体说明使用微计算机断层扫描(Micro-CT)成像和不使用造影剂来非破坏性地量化多孔性生物材料内骨、软骨和血管的形成。
Porous biomaterials designed to support cellular infiltration and tissue formation play a critical role in implant fixation and engineered tissue repair. The purpose of this Leading Opinion Paper is to advocate the use of high resolution 3D imaging techniques as a tool to quantify extracellular matrix formation and vascular ingrowth within porous biomaterials and objectively compare different strategies for functional tissue regeneration. An initial over-reliance on qualitative evaluation methods may have contributed to the false perception that developing effective tissue engineering technologies would be relatively straightforward. Moreover, the lack of comparative studies with quantitative metrics in challenging pre-clinical models has made it difficult to determine which of the many available strategies to invest in or use clinically for companies and clinicians, respectively. This paper will specifically illustrate the use of microcomputed tomography (micro-CT) imaging with and without contrast agents to nondestructively quantify the formation of bone, cartilage, and vasculature within porous biomaterials.
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影响因子：
14
作者：
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通讯作者：
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DOI：
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发表时间：
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发表时间：
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影响因子：
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作者：
Guldberg, Robert E;Lin, Angela S P;Duvall, Craig
通讯作者：
Duvall, Craig
影响因子：
2.8
作者：
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