Prevalence of insulin resistance and its relationship with cardiovascular disease risk factors among Thai adults over 35 years old.
Prevalence of insulin resistance and its relationship with cardiovascular disease risk factors among Thai adults over 35 years old.
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DOI：
10.1016/j.diabres.2010.04.013
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发表时间：
2010-09
影响因子：
5.1
通讯作者：
Williams, Michelle A.
中科院分区：
文献类型：
--
作者：
Do, Hau D.;Lohsoonthorn, Vitool;Jiamjarasrangsi, Wiroj;Lertmaharit, Somrat;Williams, Michelle A.
评估泰国成年人中胰岛素抵抗(HOMA-IR)的患病率，并研究其与选定的心血管疾病危险因素的关系。这项横断面研究包括227名男性和990名女性，他们正在接受常规健康检查。使用以前在亚洲和其他人群中使用的诊断标准来估计胰岛素抵抗的患病率。使用Spearman等级相关系数来评估HOMA-IR与选定的心血管疾病危险因素的相关性。采用多变量Logistic回归方法评估高甘油三酯血症、低高密度脂蛋白血症和高血压与不同的HOMA-IR值之间的关系。大约25.1%的男性(HOMA-IR≥1.56)和21.5%的女性(HOMA-IR≥1.64)被归类为胰岛素抵抗。HOMA-IR值与体重指数、体脂百分比、腰围和血清甘油三酯呈显著正相关。这些值与高密度脂蛋白-胆固醇呈负相关。与HOMA-IR值在最低四分位数(0.45)内的男性相比，HOMA-IR值在最高四分位数(≥1.58)的男性患高甘油三酯血症(调整后OR=2.83)、低高密度脂蛋白血症(调整后OR=2.79)和高血压(调整后OR=2.76)的风险更高。在女性中也观察到了类似的关联。用HOMA-IR确定的胰岛素抵抗与泰国成年人中选定的心血管疾病风险因素呈正相关。
To estimate the prevalence of insulin resistance (HOMA-IR) and to study its relationship with selected cardiovascular disease risk factors among Thai adults. This cross-sectional study was comprised of 227 men and 990 women undergoing routine health check-up. The prevalence of insulin resistance was estimated using diagnostic criteria previously employed in Asian and other populations. Spearman's rank correlation coefficients were used to evaluate associations of HOMA-IR with selected cardiovascular disease risk factors. Multivariable logistic regression procedures were used to evaluate associations of hypertriglyceridemia, low HDL-Cholesterolemia, and hypertension with varying HOMA-IR values. Approximately 25.1% of men (HOMA-IR ≥ 1.56) and 21.5% of women (HOMA-IR ≥1.64) were classified as having insulin resistance. HOMA-IR values were statistically significantly and positively associated with body mass index, body fat percentage, waist circumference, and serum triglycerides. The values were inversely correlated with HDL-Cholesterol. When compared with those whose HOMA-IR values were within the lowest quartile (<0.45), men with HOMA-IR values in the highest quartile (≥1.58) had higher risks of hypertriglyceridemia (adjusted OR=2.83), low HDL-Cholesterolemia (adjusted OR=2.79), and hypertension (adjusted OR=2.76). Similar associations were observed among women. Insulin resistance, as determined using HOMA-IR, was positively associated with selected cardiovascular disease risk factors among Thai adults.
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影响因子：
5.1
作者：
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通讯作者：
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